The immunobiology of aluminium adjuvants: how do they really work?

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The immunobiology of aluminium adjuvants: how do they really work?

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dc.contributor.author Exley, Christopher
dc.contributor.author Siesjö, Peter
dc.contributor.author Eriksson, Håkan
dc.date.accessioned 2010-05-18T09:32:00Z
dc.date.available 2010-05-18T09:32:00Z
dc.date.issued 2010
dc.identifier.issn 1471-4906 en
dc.identifier.uri http://hdl.handle.net/2043/10137
dc.description.abstract Aluminium adjuvants potentiate the immune response, thereby ensuring the potency and efficacy of typically sparingly available antigen. Their concomitant critical importance in mass vaccination programmes may have prompted recent intense interest in understanding how they work and their safety. Progress in these areas is stymied, however, by a lack of accessible knowledge pertaining to the bioinorganic chemistry of aluminium adjuvants, and, consequently, the inappropriate application and interpretation of experimental models of their mode of action. The objective herein is, therefore, to identify the many ways that aluminium chemistry contributes to the wide and versatile armoury of its adjuvants, such that future research might be guided towards a fuller understanding of their role in human vaccinations. en
dc.format.extent 7
dc.language.iso eng en
dc.subject vaccine en
dc.subject Al-adjuvant en
dc.subject.classification Medicine en
dc.title The immunobiology of aluminium adjuvants: how do they really work? en
dc.type Article, peer reviewed scientific en
dc.contributor.department Malmö University. Faculty of Health and Society en
dc.identifier.doi 10.1016/j.it.2009.12.009 en
dc.subject.srsc Research Subject Categories::NATURAL SCIENCES::Biology::Cell and molecular biology::Immunology en
dc.subject.srsc Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases::Immunology::Immunobiology en
dc.relation.ispartofpublication Trends in Immunolgy;3 en
dc.relation.ispartofpublicationvolume 31 en
dc.format.ePage 109
dc.format.sPage 103
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