Antibiotically resistant bacteria are multiplying at an exponential rate in today's society and are threatening to consolidate into a serious problem in hospitals around the world. MRSA is part of this phenomena. This study intends to uncover and highlight the effectiveness of nurses' compliance to preventative efforts, to the precautions associated with activity where the risk of transmission of MRSA is a constant, and the hazardous circumstances arising out of the hospital and nursing environments. To ensure that the study maintained a thoroughly systematic procedure, it was conducted in seven separate steps. Pubmed and Cinahl have been utilised in the research, where quantitative studies have been included as part of the reviewed literature. The quality of the material has been ensured by applying a review protocol. Nine articles were selected to form the base of the study, which produced results in four categories respectively – barrier care, compliance, hand hygiene and hazardous circumstances. Moderate scientific evidence prompts the assertion that proper protection against transmission requires both protective gloves and aprons to shield work clothing from contamination. Studies have furthermore shown that compliance in the area of prevention is improved through training. All the results thus support the view that the patient ought to be protected to the same degree as the nurse, as the latter may inescapably constitute an extension of disease transmission.