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  • 1.
    Truedsson, Anna
    et al.
    Malmö högskola, Faculty of Odontology (OD).
    Wang, Jian-Sheng
    Lindberg, Pia
    Malmö högskola, Faculty of Odontology (OD).
    Gordh, Monica
    Malmö högskola, Faculty of Odontology (OD).
    Sunzel, Bo
    Malmö högskola, Faculty of Odontology (OD).
    Warfvinge, Gunnar
    Malmö högskola, Faculty of Odontology (OD).
    Bone substitute as an on-lay graft on rat tibia2010In: Clinical Oral Implants Research, ISSN 0905-7161, E-ISSN 1600-0501, Vol. 21, no 4, p. 424-429Article in journal (Refereed)
    Abstract [en]

    OBJECTIVES: To investigate the capacity of Cerament, an injectable bone substitute, to guide bone generation from a cortical surface. MATERIALS AND METHOD: Cerament was applied to the cortical surface of rat tibiae and investigated histologically after 3, 6 and 12 weeks, using a procedure similar to that performed in sham-operated rats. RESULTS: In both groups, the thickness of the bone cortex increased significantly from 473 + or - 58 microm (mean + or - SD) at day 0 to 1193 + or - 255 microm (Cerament) and 942 + or - 323 microm (sham) after 3 weeks. In the Cerament group, the new bone thickness remained constant (1258 + or - 288 microm) until the end of the experiment at 12 weeks, while the sham group demonstrated a return to initial cortical thickness (591 + or - 73 microm) at 12 weeks. The newly formed bone in the Cerament group was highly trabecular after 3 weeks but attained a normal trabecular structure of the cortex after 12 weeks. CONCLUSION: Cerament may guide bone generation from an intact cortical bone surface. Although bone remodeling speed may differ between rats and humans, our study indicates that Cerament may become a useful alternative to autologous bone, both to fill defects and to increase bone volume by cortical augmentation.

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