One of the major health problems of our time is smoking. Smoking quickly leads to addiction which makes it hard to quit. The purpose of this study is to clarify whether there is scientific evidence that motivational interviewing is effective in smoking cessation for adults, without smoking-related diseases. The method used is systematic literature review. Nine articles that corresponded with the definition of the query were reviewed and included in the study. Of these articles, eight are randomized controlled trials and one article is a study with a control group but no randomization to groups. The intervention group received motivational interviewing, often with an additional intervention. Control groups in all cases received advice and support in order help them stop smoking. There are inadequate well-controlled studies to demonstrate significant effects on motivational interviewing and smoking cessation. In order to determine if motivational interviewing benefit people trying to quit smoking, larger studies and more research is required.