Flexible micro(bio)sensors for quantitative analysis of bioanalytes in a nanovolume of human lachrymal liquid

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Flexible micro(bio)sensors for quantitative analysis of bioanalytes in a nanovolume of human lachrymal liquid

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dc.contributor.author Andoralov, Viktor
dc.contributor.author Shleev, Sergey
dc.contributor.author Arnebrant, Thomas
dc.contributor.author Ruzgas, Tautgirdas
dc.date.accessioned 2013-12-20T12:10:59Z
dc.date.available 2013-12-20T12:10:59Z
dc.date.issued 2013 en_US
dc.identifier.issn 1618-2642 en_US
dc.identifier.uri http://hdl.handle.net/2043/16436
dc.description.abstract A flexible electrochemical micro(bio)sensor has been designed for determination of several biological compounds, specifically, ascorbate, dopamine, and glucose, in human lachrymal liquid (tears). The microsensor for simultaneous determination of ascorbate and dopamine concentrations was based on a gold microwire modified with the tetrathiafulvalen–7,7,8,8-tetracyanoquinodimethane complex as a catalyst. To monitor glucose concentration in tears, glucose dehydrogenase was immobilized on a gold microwire modified with carbon nanotubes and an osmium redox polymer. A capillary microcell was constructed for sampling tears. The cell had a working volume of 60–100 nL with a sampling deviation of 6.7 %. To check if the microcell was properly filled with buffer or tear sample, a control electrode was introduced into the construction. The electrode was used to measure the electrical resistance of a fully filled nanovolume cell. The mechanical flexibility is one of the most important features of the prototype and allowed direct collection of tears with minimized risk of damage to the eye. en_US
dc.format.extent 9
dc.language.iso eng en_US
dc.publisher Springer en_US
dc.subject Flexible micro(bio)sensor en_US
dc.subject Nanovolume en_US
dc.subject Tears en_US
dc.subject Ascorbate en_US
dc.subject Dopamine en_US
dc.subject Glucose en_US
dc.subject.classification Medicine en_US
dc.title Flexible micro(bio)sensors for quantitative analysis of bioanalytes in a nanovolume of human lachrymal liquid en_US
dc.type Article, peer reviewed scientific en_US
dc.contributor.department Malmö University. Faculty of Health and Society en_US
dc.contributor.department Malmö University. Biomedical Sciences (BMV) en_US
dc.subject.srsc Research Subject Categories::NATURAL SCIENCES en_US
dc.identifier.url http://link.springer.com/article/10.1007%2Fs00216-013-6756-x#page-1 en_US
dc.relation.ispartofpublication Anal Bioanal Chem;11
dc.relation.ispartofpublicationvolume 405 en_US
dc.format.ePage 3879
dc.format.sPage 3871
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