A new protocol to evaluate the effect of topical anesthesia

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A new protocol to evaluate the effect of topical anesthesia

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dc.contributor.author List, Thomas
dc.contributor.author Mojir, Katerina
dc.contributor.author Svensson, Peter
dc.contributor.author Pigg, Maria
dc.date.accessioned 2015-01-12T11:03:56Z
dc.date.available 2015-01-12T11:03:56Z
dc.date.issued 2014 en_US
dc.identifier.issn 0003-3006 en_US
dc.identifier.uri http://hdl.handle.net/2043/18464
dc.description.abstract This double-blind, placebo-controlled, randomized cross-over clinical experimental study tested the reliability, validity, and sensitivity to change of punctuate pain thresholds and self-reported pain on needle penetration. Female subjects without orofacial pain were tested in 2 sessions at 1- to 2-week intervals. The test site was the mucobuccal fold adjacent to the first upper right premolar. Active lidocaine hydrochloride 2% (Dynexan) or placebo gel was applied for 5 minutes, and sensory testing was performed before and after application. The standardized quantitative sensory test protocol included mechanical pain threshold (MPT), pressure pain threshold (PPT), mechanical pain sensitivity (MPS), and needle penetration sensitivity (NPS) assessments. Twenty-nine subjects, mean (SD) age 29.0 (10.2) years, completed the study. Test-retest reliability intraclass correlation coefficient at 10-minute intervals between examinations was MPT 0.69, PPT 0.79, MPS 0.72, and NPS 0.86. A high correlation was found between NPS and MPS (r = 0.84; P < .001), whereas NPS and PPT were not significantly correlated. The study found good to excellent test-retest reliability for all measures. None of the sensory measures detected changes in sensitivity following lidocaine 2% or placebo gel. Electronic von Frey assessments of MPT/MPS on oral mucosa have good validity. en_US
dc.format.extent 10
dc.language.iso eng en_US
dc.publisher Allen Press
dc.subject lidocaine en_US
dc.subject mechanical pain threshold en_US
dc.subject pressure pain threshold en_US
dc.subject reliability en_US
dc.subject topical aneshesia en_US
dc.subject validity en_US
dc.subject.classification Medicine en_US
dc.title A new protocol to evaluate the effect of topical anesthesia en_US
dc.type Article, peer reviewed scientific en_US
dc.contributor.department Malmö University. Faculty of Odontology
dc.identifier.doi 10.2344/0003-3006-61.4.135 en_US
dc.subject.srsc Research Subject Categories::ODONTOLOGY en_US
dc.relation.ispartofpublication Anesthesia Progress;4
dc.relation.ispartofpublicationvolume 61 en_US
dc.format.ePage 144
dc.format.sPage 135
mahlocal.rights.oaType green
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