Immunohistopathology of the Newly Discovered Giant Papillae Tongue Disorder in Organ-Transplanted Children

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Immunohistopathology of the Newly Discovered Giant Papillae Tongue Disorder in Organ-Transplanted Children

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Publication Article, peer reviewed scientific
Title Immunohistopathology of the Newly Discovered Giant Papillae Tongue Disorder in Organ-Transplanted Children
Author Alves, Fabio de Abreu ; Gale, Gita ; Molina Vivas, Ana Paula ; Porta, Gilda ; Costa, Felipe D'Almeida ; Warfwinge, Gunnar ; Jontell, Mats ; Saalman, Robert
Date 2017
English abstract
Background. Giant papillae tongue disorder (GRID) is a newly discovered, long-lasting clinical disorder that may develop in organ-transplanted pediatric recipients. The key feature of this disorder is the unique tongue lesion, which comprises swollen fungiform papillae. The aim of this study was to characterize the immunohistopathology of this novel inflammatory condition. Methods. Six organ transplanted children with GRID were included in the study. Routine histopathology and immunohistochemical stainings for CD3, CD4, CD8, CD25, FOXP3, CD20, CD138, CD68, CD1a, CD15, CD23, and mast cell tryptase were performed. Results. Immunohistochemical analyses of the oral lesions revealed a subepithelial infiltrate that was primarily composed of CD3- and CD4-positive T cells, CD20-expressing B cells, macrophages, and CD138-positive plasma cells. The CD20-positive cells did not display the typical B cell morphology, having in general a more dendritic cell-like appearance. The CD138-expressing plasma cells were distinctly localized as a dense infiltrate beneath the accumulation of T cells and B cells. Increased numbers of CD1a-expressing Langerhans cells were detected both in the epithelium and connective tissue. Because no granulomas were observed and only single lesional eosinophils were detected, GPTD does not resemble a granulomatous or eosinophilic condition. Conclusions. We describe for the first time the immunopathological characteristics of a novel inflammatory disorder of the oral cavity, which may develop after solid organ transplantation in children.
DOI https://doi.org/10.1097/TP.0000000000001205 (link to publisher's fulltext.)
Publisher Lippincott Williams & Wilkins
Host/Issue Transplantation;6
Volume 101
ISSN 0041-1337
Pages 1441-1448
Language eng (iso)
Subject Immunology
Surgery
Transplantation
Medicine
Research Subject Categories::MEDICINE
Handle http://hdl.handle.net/2043/23482 Permalink to this page
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