Increased Plasma Levels of Circulating Cell-Free Mitochondrial DNS in Suicide Attempters - Associations with HPA-Axis Hyperactivity

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Increased Plasma Levels of Circulating Cell-Free Mitochondrial DNS in Suicide Attempters - Associations with HPA-Axis Hyperactivity

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Title Increased Plasma Levels of Circulating Cell-Free Mitochondrial DNS in Suicide Attempters - Associations with HPA-Axis Hyperactivity
Author Lindqvist, Daniel ; Fernström, Johan ; Grudet, Cécile ; Ljunggren, Lennart ; Träskman-Bendz, Lil ; Ohlsson, Lars ; Westrin, Åsa
Date 2017
English abstract
Background: Preclinical data suggest that chronic stress may cause cellular damage and mitochondrial dysfunction, potentially leading to the release of mitochondrial DNA (mtDNA) into the bloodstream. Major Depressive Disorder has been associated with an increased amount of mtDNA in leukocytes from saliva samples and blood, but no previous studies have measured plasma levels of free-circulating mtDNA in a clinical psychiatric sample. Methods: In this study, free circulating mtDNA was quantified in plasma samples from 37 suicide attempters, who had undergone a dexamethasone suppression test (DST), and 37 healthy controls. We hypothesized that free circulating mtDNA would be elevated in the suicide attempters and associated with hypothalamic pituitary adrenal (HPA)-axis hyperactivity. Results: Suicide attempters had significantly higher plasma levels of free-circulating mtDNA compared to healthy controls at different time points (pre- and post-DST) (all p-values ,2.98E-12, Cohen’s d ranging from 2.55-4.01). Pre-DST plasma levels of mtDNA were positively correlated with postDST cortisol levels (rho50.49, p,0.003). Conclusions: Suicide attempters may have elevated plasma levels of free-circulating mtDNA, which are related to impaired HPA-axis negative feedback. This peripheral index is consistent with increased cellular or mitochondrial damage. The specific cells and tissues contributing to plasma levels of free-circulating mtDNA are not known, as is the specificity of this finding for suicide attempters. Future studies are needed in order to better understand the relevance of increased freecirculating mtDNA in relation to the pathophysiology underlying suicidal behavior and depression.
Conference
2017 annual meeting of the Society of Biological Psychiatry : Networks and Complexity in Biology, Brain and Behavior (May 18-20, 2017 : San Diego, California)
Link https://www.sciencedirect.com/science/article/pii/... (external link to publication)
Publisher Elsevier
Host/Issue Biological Psychiatry;10
Volume 81
ISSN 0006-3223
Pages 1
Article#/Abstract# 565
Page S228-S228
Language eng (iso)
Subject Neurosciences
Psychiatry
Medicine
Research Subject Categories::NATURAL SCIENCES
Handle http://hdl.handle.net/2043/23487 Permalink to this page
Link https://sobp.org/meetings/past-meetings/... (external link to related web page)
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