The effect of magnesium on early osseointegration in osteoporotic bone : a histological and gene expression investigation

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The effect of magnesium on early osseointegration in osteoporotic bone : a histological and gene expression investigation

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Publication Article, peer reviewed scientific
Title The effect of magnesium on early osseointegration in osteoporotic bone : a histological and gene expression investigation
Author Galli, Silvia ; Stocchero, Michele ; Andersson, M. ; Karlsson, J. ; He, W. ; Lilin, T. ; Wennerberg, Ann ; Jimbo, Ryo
Date 2017
English abstract
Magnesium has a key role in osteoporosis and could enhance implant osseointegration in osteoporotic patients. Titanium implants impregnated with Mg ions were installed in the tibia of ovariectomized rats. The release of Mg induced a significant increase of bone formation and the expression of anabolic markers in the peri-implant bone. The success of endosseous implants is highly predictable in patients possessing normal bone status, but it may be impaired in patients with osteoporosis. Thus, the application of strategies that adjuvate implant healing in compromized sites is of great interest. Magnesium has a key role in osteoporosis prevention and it is an interesting candidate for this purpose. In this study, the cellular and molecular effects of magnesium release from implants were investigated at the early healing stages of implant integration. Osteoporosis was induced in 24 female rats by means of ovariectomy and low-calcium diet. Titanium mini-screws were coated with mesoporous titania films and were loaded with magnesium (test group) or left as native (control group). The implants were inserted in the tibia and femur of the rats. One, 2 and 7 days after implantation, the implants were retrieved and histologically examined. In addition, expression of genes was evaluated in the peri-implant bone tissue at day 7 by means of quantitative polymerase chain reactions with pathway-oriented arrays. The histological evaluation revealed that new bone formation started already during the first week of healing for both groups. However, around the test implants, new bone was significantly more abundant and spread along a larger surface of the implants. In addition, the release of magnesium induced a significantly higher expression of BMP6. These results provide evidence that the release of magnesium promoted rapid bone formation and the activation of osteogenic signals in the vicinity of implants placed in osteoporotic bone.
DOI https://doi.org/10.1007/s00198-017-4004-5 (link to publisher's fulltext.)
Link https://link.springer.com/article/10.1007%2Fs00198-017-4004-5 .Icon
Publisher Springer
Host/Issue Osteoporosis International;7
Volume 28
ISSN 0937-941X
Pages 2195-2205
Language eng (iso)
Subject Implant surface
In vivo
Magnesium
Mesoporous titania
Osseointegration
Osteoporosis
Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/23636 Permalink to this page
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