Colony stimulating factor-1 in saliva in relation to age, smoking, and oral and systemic diseases

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Colony stimulating factor-1 in saliva in relation to age, smoking, and oral and systemic diseases

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Publication Article, peer reviewed scientific
Title Colony stimulating factor-1 in saliva in relation to age, smoking, and oral and systemic diseases
Author Lira-Junior, Ronaldo ; Åkerman, Sigvard ; Gustafsson, Anders ; Klinge, Björn ; Boström, Elisabeth A.
Date 2017
English abstract
Colony stimulating factor (CSF)-1 is a growth factor that stimulates the survival, proliferation and differentiation of mononuclear phagocytes, which has been implicated in several inflammatory diseases. This study evaluated the possible influence of age, sex, smoking, periodontitis, caries, and several systemic conditions on salivary levels of CSF-1. Four-hundred and forty-one individuals were enrolled in this study. All participants answered a health questionnaire and underwent a comprehensive oral examination. Stimulated saliva was collected and CSF-1 levels were analysed by enzyme-linked immunosorbent assay. Salivary levels of CSF-1 were significantly increased in participants over 64 years old and in non-smoking individuals, whereas no difference was observed between men and women. Individuals having periodontitis and manifest caries had significantly higher levels of CSF-1. Participants with muscle and joint disease exhibited increased CSF-1 levels as compared to those without. Age, smoking, percentage of pockets >= 4 mm, number of manifest caries lesions, and presence of tumor were associated with CSF-1 levels. Salivary levels of CSF-1 are associated with age, smoking, periodontitis, manifest caries, and the presence of muscle and joint diseases and tumors. CSF-1 might be a promising biomarker candidate in saliva of both local and systemic conditions that needs further investigation.
DOI https://doi.org/10.1038/s41598-017-07698-4 (link to publisher's fulltext.)
Link https://www.nature.com/articles/s41598-017-07698-4... (external link to publication)
Publisher Nature Publishing Group
Host/Issue Scientific Reports;
Volume 7
ISSN 2045-2322
Language eng (iso)
Subject Multidisciplinary Sciences
Sciences
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/23646 Permalink to this page
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