Colony stimulating factor-1 in saliva in relation to age, smoking, and oral and systemic diseases

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Colony stimulating factor-1 in saliva in relation to age, smoking, and oral and systemic diseases

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dc.contributor.author Lira-Junior, Ronaldo
dc.contributor.author Åkerman, Sigvard
dc.contributor.author Gustafsson, Anders
dc.contributor.author Klinge, Björn
dc.contributor.author Boström, Elisabeth A.
dc.date.accessioned 2017-11-02T14:31:36Z
dc.date.available 2017-11-02T14:31:36Z
dc.date.issued 2017 en_US
dc.identifier.issn 2045-2322 en_US
dc.identifier.uri http://hdl.handle.net/2043/23646
dc.description.abstract Colony stimulating factor (CSF)-1 is a growth factor that stimulates the survival, proliferation and differentiation of mononuclear phagocytes, which has been implicated in several inflammatory diseases. This study evaluated the possible influence of age, sex, smoking, periodontitis, caries, and several systemic conditions on salivary levels of CSF-1. Four-hundred and forty-one individuals were enrolled in this study. All participants answered a health questionnaire and underwent a comprehensive oral examination. Stimulated saliva was collected and CSF-1 levels were analysed by enzyme-linked immunosorbent assay. Salivary levels of CSF-1 were significantly increased in participants over 64 years old and in non-smoking individuals, whereas no difference was observed between men and women. Individuals having periodontitis and manifest caries had significantly higher levels of CSF-1. Participants with muscle and joint disease exhibited increased CSF-1 levels as compared to those without. Age, smoking, percentage of pockets >= 4 mm, number of manifest caries lesions, and presence of tumor were associated with CSF-1 levels. Salivary levels of CSF-1 are associated with age, smoking, periodontitis, manifest caries, and the presence of muscle and joint diseases and tumors. CSF-1 might be a promising biomarker candidate in saliva of both local and systemic conditions that needs further investigation. en_US
dc.language.iso eng en_US
dc.publisher Nature Publishing Group
dc.subject Multidisciplinary Sciences en_US
dc.subject.classification Sciences en_US
dc.title Colony stimulating factor-1 in saliva in relation to age, smoking, and oral and systemic diseases en_US
dc.type Article, peer reviewed scientific en_US
dc.contributor.department Malmö University. Faculty of Odontology
dc.identifier.doi 10.1038/s41598-017-07698-4 en_US
dc.subject.srsc Research Subject Categories::ODONTOLOGY en_US
dc.identifier.url https://www.nature.com/articles/s41598-017-07698-4 en_US
dc.relation.ispartofpublication Scientific Reports;
dc.relation.ispartofpublicationvolume 7 en_US
dc.description.authorversion No en_US
dc.identifier.isiid 000406980800019
mahlocal.rights.oaType gold
mahlocal.rights.oaType green
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