Antifungal and Mechanical Properties of Tissue Conditioner Containing Plant-Derived Component : An In Vitro Study

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Antifungal and Mechanical Properties of Tissue Conditioner Containing Plant-Derived Component : An In Vitro Study

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Publication Article, peer reviewed scientific
Title Antifungal and Mechanical Properties of Tissue Conditioner Containing Plant-Derived Component : An In Vitro Study
Author Naito, Yoshihito ; Yumoto, Hiromichi ; Kumar, Kiran ; Matsuo, Takashi ; Hirota, Katsuhiko ; Miyake, Yoichiro ; Nagao, Kan ; Tomotake, Yoritoki ; Jimbo, Ryo ; Ichikawa, Tetsuo
Date 2018
English abstract
Purpose: To evaluate the antifungal activity and mechanical properties of a novel antifungal tissue conditioner containing Juncus powder. Materials and Methods: Juncus powder was mixed with GC tissue conditioner at concentrations of 2.5%, 5.0%, and 10.0% by mass. The cylindrical specimens of Juncus-mixed tissue conditioner (dimensions: 10 mm in diameter and 2 and 6 mm in height for antimicrobial and mechanical tests, respectively) were prepared. The specimens placed on the bottom of the 24-well tissue culture plate were cultured with Candida albicans CAD1 for 2 and 4 days. The proliferation of the C. albicans in the wells was determined by measuring the optical density of fungal culture, and the surface of the specimens were also observed by scanning electron microscopy (SEM). To assess the mechanical properties of the specimens, the fluidity and hardness of Juncus-mixed tissue conditioner were measured using the methods certified according to ISO 10139-1. Results: Juncus-mixed tissue conditioner significantly exhibited growth inhibitory effect in a Juncus concentration-dependent manner after both 2- and 4- day cultures. SEM observation showed that the amount of C. albicans on Juncus-mixed specimens drastically decreased, and biofilm formation was markedly inhibited. Moreover, both mechanical properties were found to be within the ranges regulated and specified by ISO. Conclusion: These findings demonstrated that the tissue conditioner including Juncus powder has a significant growth inhibitory effect against C. albicans, and it is suggested that the application of Juncus-mixed tissue conditioner may prevent denture stomatitis and oral candidiasis in denture wearers.
DOI https://doi.org/10.1111/jopr.12546 (link to publisher's fulltext.)
Link http://onlinelibrary.wiley.com/doi/10.1111/jopr.12... (external link to publication)
Publisher Wiley
Host/Issue Journal of Prosthodontics;7
Volume 27
ISSN 1059-941X
1532-849X
Language eng (iso)
Subject Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/23841 Permalink to this page
Link to publication in DiVA Find this research publication in DiVA (n/a for student publ.)
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