The impact of surface roughness and permeability in hydroxyapatite bone regeneration membranes

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The impact of surface roughness and permeability in hydroxyapatite bone regeneration membranes

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Publication Article, peer reviewed scientific
Title The impact of surface roughness and permeability in hydroxyapatite bone regeneration membranes
Author Anderud, Jonas ; Jimbo, Ryo ; Abrahamsson, Peter ; Adolfsson, Erik ; Malmström, Johan ; Wennerberg, Ann
Date 2016
English abstract
Background One of the crucial aspects in guided bone regeneration is the space maintenance. This is normally created by a membrane, which should primarily be accepted by the surrounding tissues without causing any adverse reactions. The impact of surface topography, biological acceptance as well as permeability of these membranes has been carefully discussed in the literature. Purpose The purpose of this study was to evaluate histologically the bone forming properties inside of hollow hydroxyapatite space-maintaining devices with different inner surfaces and different permeabilities in an animal calvaria model in vivo. Materials and methods A total of 36 hollow domes with three different designs made of hydroxyapatite were surgically attached to the skulls of rabbits. Group 1 had a moderately rough inner surface. Group 2 had a smooth inner surface. Group 3 had the same properties as Group 1 but had macroscopic holes on the top. The domes were left to heal for 12 weeks and were then processed for undecalcified ground sectioning. Histological evaluations were performed using a light microscope and scanning electron microscopy. The bone–implant contact (BIC) percentage along the device was calculated. Results The median percentage of BIC was higher for Group 1 compared with Group 2 (P = 0.004). Group 1 produced a larger median BIC compared with Group 3 (P < 0.0001). Conclusions Within the limits of this preclinical study, these findings suggest that a moderately rough inner surface of a ceramic membrane along with a non-permeable device produces more bone than a smooth inner surface.
DOI https://doi.org/10.1111/clr.12717 (link to publisher's fulltext.)
Link http://onlinelibrary.wiley.com/doi/10.1111/clr.127... (external link to publication)
Publisher Wiley
Host/Issue Clinical oral implants research; 8
Volume 27
ISSN 1600-0501
Language eng (iso)
Subject animal experiments
biomaterials
bone regeneration
guided tissue regeneration
surface chemistry
Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/23854 Permalink to this page
Link to publication in DiVA Find this research publication in DiVA (n/a for student publ.)
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