Osteoimmunological Aspects of Periodontal Diseases

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Osteoimmunological Aspects of Periodontal Diseases

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Publication BookChapter
Title Osteoimmunological Aspects of Periodontal Diseases
Author Bertl, Kristina ; Pietschmann, Peter ; Stavropoulos, Andreas
Editor Pietschmann, Peter
Date 2016
English abstract
Osteoimmunology describes the cross-talk of cells of the musculoskeletal and the immune system during the pathogenesis of various diseases; among the most prevalent ones is periodontitis, a chronic infectious inflammatory disease of the tooth-supporting structures, i.e., the periodontium consisting of the gingiva, alveolar bone, periodontal ligament, and root cementum. Periodontal disease is initiated by oral pathogens that accumulate at the gingival margin of the teeth and thereby trigger a response of the innate and adaptive immunity. In contrast to other osteoimmunological disorders (e.g., osteoporosis, rheumatoid arthritis), the immune system plays a two-sided role in the pathogenesis of periodontitis: it controls the infection and protects the organism from bacterial invasion but also propagates the destruction of the soft and hard tissues surrounding the tooth. Periodontitis, if left untreated, finally results in tooth loss.
DOI https://doi.org/10.1007/978-3-319-34238-2_12 (link to publisher's fulltext.)
Publisher Springer
Host/Issue Principles of Osteoimmunology : Molecular Mechanisms and Clinical Applications
ISBN 978-3-319-34236-8
978-3-319-34238-2
Language eng (iso)
Subject pathogenesis
osteoimmunology
periodontitis
Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/23905 Permalink to this page
Link to publication in DiVA Find this research publication in DiVA (n/a for student publ.)
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