Multivalent mesoporous silica nanoparticles photodelivering nitric oxide with carbon dots as fluorescent reporters

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Multivalent mesoporous silica nanoparticles photodelivering nitric oxide with carbon dots as fluorescent reporters

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Publication Article, peer reviewed scientific
Title Multivalent mesoporous silica nanoparticles photodelivering nitric oxide with carbon dots as fluorescent reporters
Author Afonso, Damien ; Valetti, Sabrina ; Fraix, Aurore ; Bascetta, Claudia ; Petralia, Salvatore ; Conosci, Sabrina ; Feiler, Adam ; Sortino, Salvatore
Research Centre Biofilms - Research Center for Biointerfaces
Date 2017
English abstract
Amino-terminated mesoporous silica nanoparticles embedding carbon dots (MSCD) formed by calcination were functionalized with a nitric oxide (NO) photodonor (1) to give a robust MSCD-1 conjugate. The intense fluorescence of MSCDs was strongly quenched in MSCD-1 by effective energy transfer. Visible light excitation of MSCD-1 liberates NO, suppresses the energy transfer mechanism and leads to concomitant fluorescence restoration of the MSCD scaffold, which acts as an optical reporter for the released NO. The MSCD-1 hybrid is also able to encapsulate the highly hydrophobic photosensitizer temoporfin, preserving the fluorescence reporting function.
DOI https://doi.org/10.1039/C7NR04832G (link to publisher's fulltext.)
Publisher Royal Society of Chemistry
Host/Issue Nanoscale;
Volume 9
ISSN 2040-3372
Language eng (iso)
Subject Technology
Research Subject Categories::TECHNOLOGY
Handle http://hdl.handle.net/2043/24194 Permalink to this page
Link to publication in DiVA Find this research publication in DiVA.
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