Targeted Photodynamic Therapy with a Folate/Sensitizer Assembly Produced from Mesoporous Silica

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Targeted Photodynamic Therapy with a Folate/Sensitizer Assembly Produced from Mesoporous Silica

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Publication Article, peer reviewed scientific
Title Targeted Photodynamic Therapy with a Folate/Sensitizer Assembly Produced from Mesoporous Silica
Author Zhou, Chunfang ; Afonso, Damien ; Valetti, Sabrina ; Feiler, Adam ; Cardile, Venera ; Graziano, Adriana C.E. ; Conoci, Sabrina ; Sortino, Salvatore
Research Centre Biofilms - Research Center for Biointerfaces
Date 2017
English abstract
A mesoporous silica material prepared by using folic acid (FA) as a template enables the effective encapsulation of meso-tetrakis(4-carboxyphenyl)porphyrin (TCPP) in its interior. Combination of steady-state and time-resolved absorption and emission spectroscopy demonstrate that FA and TCPP are released from the silica material to the aqueous phase in the form of a non-covalent assembly. This assembly does not form by simple mixing of the two components in the absence of silica, suggesting the key role of the material in the assembling process. The FA/TCPP assembly exhibits dual color fluorescence in the visible region, good photosensitization capability of singlet oxygen, and enhanced photo-induced mortality in KB cancer cells overexpressing folate receptor, if compared with the free components.
DOI https://doi.org/10.1002/chem.201701432 (link to publisher's fulltext.)
Link http://rdcu.be/DtrR/... (external link to publication)
Publisher Wiley
Host/Issue Chemistry : A European Journal;32
Volume 23
ISSN 1521-3765
Language eng (iso)
Subject Technology
Research Subject Categories::PHARMACY
Handle http://hdl.handle.net/2043/24198 Permalink to this page
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