Chitosan-Dextran Sulfate Hydrogels as a Potential Carrier for Probiotics

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Chitosan-Dextran Sulfate Hydrogels as a Potential Carrier for Probiotics

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Publication Article, peer reviewed scientific
Title Chitosan-Dextran Sulfate Hydrogels as a Potential Carrier for Probiotics
Author Falco, Cigdem Yucel ; Falkman, Peter ; Risbo, Jens ; Cárdenas, Marité ; Medronho, Bruno
Research Centre Biofilms - Research Center for Biointerfaces
Date 2017
English abstract
Physical and chemical (crosslinked with genipin) hydrogels based on chitosan and dextran sulfate were developed and characterized as novel bio-materials suitable for probiotic encapsulation. The swelling of the hydrogels was dependent on the composition and weakly influenced by the pH of the media. The morphology analysis supports the swelling data showing distinct changes in microstructure depending on the composition. The viability and culturability tests showed approx. 3.6 log CFU/mL decrease of cells (L. acidophilus as model) incorporated into chemical hydrogels when compared to the number of viable native cells. However, the live/dead viability assay evidenced that a considerable amount of viable cells were still entrapped in the hydrogel network and therefore the viability is most likely underestimated. Overall, the developed systems are robust and their structure, rheology and swelling properties can be tuned by changing the blend ratio, thus constituting appealing bio-matrices for cell encapsulation.
DOI https://doi.org/10.1016/j.carbpol.2017.04.047 (link to publisher's fulltext.)
Publisher Elsevier
Host/Issue Carbohydrate Polymers;
Volume 172
ISSN 0144-8617
Language eng (iso)
Subject Chitosan
Dextran sulfate
Genipin
Hydrogel
Encapsulation
Probiotic bacteria
Sciences
Research Subject Categories::NATURAL SCIENCES
Handle http://hdl.handle.net/2043/24200 Permalink to this page
Link to publication in DiVA Find this research publication in DiVA (n/a for student publ.)
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