Peripheral giant cell granuloma : an updated analysis of 2824 cases reported in the literature

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Peripheral giant cell granuloma : an updated analysis of 2824 cases reported in the literature

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Publication Article, review peer-reviewed scientific
Title Peripheral giant cell granuloma : an updated analysis of 2824 cases reported in the literature
Author Chrcanovic, Bruno ; Cavalieri Gomes, Carolina ; Santiago Gomez, Ricardo
Date 2018
English abstract
Objective. To integrate the available data published on peripheral giant cell granuloma (PGCG) into a comprehensive analysis of its clinical/radiologic features. Materials and Methods. An electronic search was undertaken in January/2018 in 5 databases, looking for publications reporting cases of PGCGs. Probability of recurrence was calculated for some variables. Results. 165 publications were included, 2824 lesions identified. PGCGs were slightly more prevalent in women and more prevalent in mandibles, usually asymptomatic, and presenting erosion of the subjacent bone in almost 1/3 of cases. Additional curettage (2.8%) or peripheral osteotomy (0%) after excision presented lower recurrence rates in comparison to excision alone (16%). Excision followed by curettage decreases the probability of recurrence by 85% in comparison to excision alone. Other factors (age, lesion size, follow-up, gender, location, clinical symptoms, bone erosion) seem to do not influence the probability of recurrence. Conclusions. As surgical excision alone shows a considerable recurrence rate, excision followed by an additional therapy - curettage or peripheral osteotomy - should be the first choice of treatment of PGCG.
DOI https://doi.org/10.1111/jop.12706 (link to publisher's fulltext.)
Publisher Wiley
Host/Issue Journal of Oral Pathology and Medicine;
ISSN 1600-0714
Language eng (iso)
Subject Peripheral giant cell granuloma
Giant cell lesion
Clinical features
Treatment
Recurrence rate
Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/24773 Permalink to this page
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