Stimuli-responsive lipid bilayer mimics for protein, virus and cell recognition

DSpace Repository

Stimuli-responsive lipid bilayer mimics for protein, virus and cell recognition

Details

Files for download
Icon
Thesis without papers
Overview of item record
Publication Doctoral Thesis
Title Stimuli-responsive lipid bilayer mimics for protein, virus and cell recognition
Author Yeung, Sing Yee
Date 2018
English abstract
The most well-studied two-dimensional biomimetic cellular membrane models are self-assembled monolayers (SAMs) and supported lipid bilayers (SLBs). The former has the advantage of control over ligand density, homogeneity and orientation, allowing unambiguous interaction studies. It however lacks longrange lateral mobility, which is one of the most important aspects of cellular membranes. SLBs are laterally mobile but they are fragile and instable upon exposure to air. Literature examples that contain all the above desirable characteristics with stimuli-responsiveness to fabricate biomaterials for biosensing or modulating cell adhesion are rare. We here report on an adaptable platform, reversible self-assembled monolayers (rSAMs), featuring strongly enhanced affinity towards influenza viruses as compared to SAMs, lateral mobility to investigate glycan-lectin interactions and tunable surface dynamics to modulate cell adhesion. This new system utilizes noncovalent amidinium-carboxylate ion pairs for building up stable and ordered twodimensional assemblies, akin to lipid bilayers but with a simple preparation process, stimuli-responsiveness and fast on/off rates.
DOI https://doi.org/10.24834/2043/24967 (link to publisher's fulltext.)
Publisher Malmö university, Faculty of Health and Society
Series/Issue Malmö University Health and Society Doctoral Dissertation;7
ISSN 1653-5383
ISBN 9789171049261
9789171049278
Pages 68
Language eng (iso)
Subject Lipid bilayers
Adaptable
Self-assembled
Monolayers
Supramolecular chemistry
Cell adhesion
Biocensor
Sciences
Research Subject Categories::NATURAL SCIENCES
Included papers
  1. I. Yeung, S. Y.; Mucha, A.; Deshmukh, R.; Boutrus, M.; Arnebrant, T.; Sellergren, B. Reversible self-assembled monolayers (rSAMs): adaptable surfaces for enhanced multivalent interactions and ultrasensitive virus detection. ACS Central Science, 3 (2017) 1198- 1207

  2. II. Yeung, S. Y.; Ederth, T.; Pan, G.; Malcaité, E.; Chaturvedi, V.; Sellergren, B. pH-switchable lipid bilayer-like monolayers with ultrahigh lectin affinity, Submitted.

  3. III. Yeung, S. Y.; Ederth, T.; Pan, G.; Cicénaité, J.; Cárdenas, M.; Arnebrant, T.; Sellergren, B. Reversible self-assembled monolayers (rSAMs) as robust and fluidic lipid bilayer mimics. Langmuir, 34 (2018) 4107-4115.

  4. IV. Yeung, S. Y.; Pan, G.; Ederth, T.; El-Schich, Z.; Tran, T.; Holmqvist, B.; Sellergren, B.; Reversible self-assembled monolayers (rSAMs) with tunable surface dynamics modulate cell adhesion behaviour, Manuscript.

Handle http://hdl.handle.net/2043/24967 Permalink to this page
Facebook

This item appears in the following Collection(s)

Details

Search


Browse

My Account

Statistics