The GRADE Working Group clarifies the construct of certainty of evidence

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The GRADE Working Group clarifies the construct of certainty of evidence

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Publication Article, peer reviewed scientific
Title The GRADE Working Group clarifies the construct of certainty of evidence
Author Hultcrantz, Monica ; Rind, David ; Akl, Elie A. ; Treweek, Shaun ; Mustafa, Reem A. ; Iorio, Alfonso ; Alper, Brian S. ; Meerpohl, Joerg J. ; Murad, M. Hassan ; Ansari, Mohammed T. ; Katikireddi, Srinivasa Vittal ; Östlund, Pernilla ; Tranæus, Sofia ; Christensen, Robin ; Gartlehner, Gerald ; Brozek, Jan ; Izcovich, Ariel ; Schünemann, Holger ; Guyatt, Gordon
Date 2017
English abstract
Objective: To clarify the grading of recommendations assessment, development and evaluation (GRADE) definition of certainty of evidence and suggest possible approaches to rating certainty of the evidence for systematic reviews, health technology assessments, and guidelines. Study Design and Setting: This work was carried out by a project group within the GRADE Working Group, through brainstorming and iterative refinement of ideas, using input from workshops, presentations, and discussions at GRADE Working Group meetings to produce this document, which constitutes official GRADE guidance. Results: Certainty of evidence is best considered as the certainty that a true effect lies on one side of a specified threshold or within a chosen range. We define possible approaches for choosing threshold or range. For guidelines, what we call a fully contextualized approach requires simultaneously considering all critical outcomes and their relative value. Less-contextualized approaches, more appropriate for systematic reviews and health technology assessments, include using specified ranges of magnitude of effect, for example, ranges of what we might consider no effect, trivial, small, moderate, or large effects. Conclusion: It is desirable for systematic review authors, guideline panelists, and health technology assessors to specify the threshold or ranges they are using when rating the certainty in evidence. (C) 2017 The Authors. Published by Elsevier Inc.
DOI https://doi.org/10.1016/j.jclinepi.2017.05.006 (link to publisher's fulltext.)
Link https://www.sciencedirect.com/science/article/pii/S089543561630703X .Icon
Publisher Pergamon Press
Host/Issue Journal of Clinical Epidemiology
Volume 87
ISSN 0895-4356
Language eng (iso)
Subject GRADE
Certainty of evidence
Thresholds
Guidelines
Systematic reviews
Health technology assessment
Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/25532 Permalink to this page
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