Development of a plastic membrane containing micro-hole(s) for a potential bio-sensing application

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Development of a plastic membrane containing micro-hole(s) for a potential bio-sensing application

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Publication Article, peer reviewed scientific
Title Development of a plastic membrane containing micro-hole(s) for a potential bio-sensing application
Author Krikstolaityte, Vida ; Ruzgas, Tautgirdas ; Heiskanen, Arto ; Canali, Chiara ; Arnebrant, Thomas ; Emneus, Jenny
Date 2017
English abstract
In this work, a poly (methyl methacrylate) membrane containing micro-holes (MHs) as a prototype of a simple sensing platform of a lab-on-a-chip device has been developed for a potential analysis of clinical fluidic samples. A four probe electrochemical impedance spectroscopy (EIS) setup, with two electrodes placed on each side of the membrane, was adopted for monitoring the MH impedance (Fig. 1a). The setup was used to investigate, if EIS is suitable to sense the trapping of an analyte inside the MHs. Latex micro-beads with a diameter of 10 mu m were used to test clogging of the MHs. Additionally, finite element model simulations were performed using Comsol Multiphysics software to theoretically evaluate the sensitivity field of the EIS measurement along the MHs. (C) 2017 The Authors. Published by Elsevier Ltd.
Conference
Biosensors (25–27 May 2016 : Gothenburg, Sweden)
DOI https://doi.org/10.1016/j.protcy.2017.04.108 (link to publisher's fulltext.)
Link https://www.sciencedirect.com/science/article/pii/S2212017317301093 .Icon
Publisher Elsevier
Host/Issue Procedia Technology;Special Issue Biosensors 2016
Volume 27
ISSN 2212-0173
Language eng (iso)
Subject poly(methylmethacrylate)
lab-on-a-chip
electrochemical impedance spectroscopy
finite element model simulations
Technology
Research Subject Categories::TECHNOLOGY
Handle http://hdl.handle.net/2043/25561 Permalink to this page
Link https://www.elsevier.com/events/conferences/world-... (external link to related web page)
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