The most commonly used method to examine the heart’s morphology, anatomy and function within clinical context is 2-dimensional echocardiography. When assessing the heart’s global systolic ventricular function and wall mobility the left ventricular ejection fraction (LVEF) is utilized. To aid with the visual assessment, semi-automatic measurements and calculations are often used. These computerized methods automatically measure the heart volume using the reference point’s outline at the endocardium. The aim of this study is to compare a semi-automatic LVEF-assessment method, automated 2D cardiac quantification (a2DQ), to visually assessed LVEF using transthoracic echocardiography. Recorded ultrasound sequences from 50 previously performed ultrasound studies were included in the study. Patients with arrhythmias such as atrial fibrillation were excluded. In the study, an estimated LVEF obtained with the semiautomatic method a2DQ was compared to a visually evaluated LVEF performed by experienced examiner. LVEF was initially compared to> 55% <55% for the two methods. In addition, further comparison was made according to the following criteria> 55%, 45-54%, 30-44% and <30%. Kappa analysis related to the initial assessment showed moderate consistency (k = 0.47). Corresponding analysis made on the categorized criteria obtained a kappa coefficient of 0.41. The visual assessment gives higher LVEF in this study. The study suggests that a2DQ is a less appropriate method as it underestimates LVEF and should not be recommended as support for inexperienced examiners.