Antibiotic prophylaxis in orthognathic surgery : A complex systematic review

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Antibiotic prophylaxis in orthognathic surgery : A complex systematic review

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Publication Article, review peer-reviewed scientific
Title Antibiotic prophylaxis in orthognathic surgery : A complex systematic review
Author Naimi-Akbar, Aron ; Hultin, Margareta ; Klinge, Anna ; Klinge, Björn ; Tranaeus, Sofia ; Lund, Bodil
Date 2018
English abstract
Objective In orthognathic surgery, antibiotics are prescribed to reduce the risk of postoperative infection. However, there is lack of consensus over the appropriate drug, the dose and duration of administration. The aim of this complex systematic review was to assess the effect of antibiotics on postoperative infections in orthognathic surgery. Methods Both systematic reviews and primary studies were assessed. Medline (OVID), The Cochrane Library (Wiley) and EMBASE (embase.com), PubMed (non-indexed articles) and Health Technology Assessment (HTA) publications were searched. The primary studies were assessed using GRADE and the systematic reviews by AMSTAR. Results Screening of abstracts yielded 6 systematic reviews and 36 primary studies warranting full text scrutiny. In total, 14 primary studies were assessed for risk of bias. Assessment of the included systematic reviews identified two studies with a moderate risk of bias, due to inclusion in the meta-analyses of primary studies with a high risk of bias. Quality assessment of the primary studies disclosed one with a moderate risk of bias and one with a low risk. The former compared a single dose of antibiotic with 24 hour prophylaxis using the same antibiotic; the latter compared oral and intravenous administration of antibiotics. Given the limited number of acceptable studies, no statistical analysis was undertaken, as it was unlikely to contribute any relevant information. Conclusion With respect to antibiotic prophylaxis in orthognathic surgery, most of the studies to date have been poorly conducted and reported. Thus scientific uncertainty remains as to the preferred antibiotic and the optimal duration of administration.
DOI https://doi.org/10.1371/journal.pone.0191161 (link to publisher's fulltext.)
Link http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0191161 .Icon
Publisher Public Library of Science
Host/Issue PLOS ONE;1
Volume 13
ISSN 1932-6203
Language eng (iso)
Subject Multidisciplinary Sciences
Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/25828 Permalink to this page
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