Arginine and Caries Prevention : A Systematic Review

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Arginine and Caries Prevention : A Systematic Review

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Publication Article, review peer-reviewed scientific
Title Arginine and Caries Prevention : A Systematic Review
Author Astvaldsdottir, Alfheiour ; Naimi-Akbar, Aron ; Davidson, Thomas ; Brolund, Agneta ; Lintamo, Laura ; Granath, Anna Attergren ; Tranaeus, Sofia ; Östlund, Pernilla
Date 2016
English abstract
Objectives: To evaluate the available evidence that the use of arginine-containing dental care products prevents the development of new caries lesions and the progression of existing lesions. Search Methods: We performed a systematic literature search of databases including PubMed, the Cochrane Library and EMBASE. Selection Criteria: We selected randomized controlled trials of treatment with arginine in fluoride-containing dental products measuring dental caries incidence or progression in children, adults and elderly subjects. Data Collection and Analysis: Two review authors independently assessed trials for risk of bias and evaluated overall study quality using the GRADE classification. Main Results: Due to conflicts of interest and weak transferability to Swedish conditions, no conclusions can be drawn from studies on the effects of arginine-fluoride toothpaste in children. Arginine-containing toothpaste costs about 40% more than basic fluoride toothpaste; to determine whether it is more cost-effective, the higher cost must be considered in relation to any additional caries-preventive effect. The literature review also disclosed some questionable research ethics: in several of the studies, the children in the control group used non-fluoride toothpaste. Toothpaste without fluoride is not as effective against dental caries as the standard treatment - fluoride toothpaste - which has a well -documented effect. This contravenes the fundamental principles of research ethics. Conclusion: At present there is insufficient evidence in support of a caries-preventive effect for the inclusion of arginine in toothpastes. More rigorous studies, and studies which are less dependent on commercial interests, are required. (C) 2016 S. Karger AG, Basel
DOI https://doi.org/10.1159/000446249 (link to publisher's fulltext.)
Publisher Karger
Host/Issue Caries Research;4
Volume 50
ISSN 0008-6568
Language eng (iso)
Subject Arginine
Arginine-fluoride toothpaste
Caries
Caries prevention
Dental care
Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/25907 Permalink to this page
Link to publication in DiVA Find this research publication in DiVA.
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