Tissue Reaction to a Novel Bone Substitute Material Fabricated With Biodegradable Polymer-Calcium Phosphate Nanoparticle Composite

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Tissue Reaction to a Novel Bone Substitute Material Fabricated With Biodegradable Polymer-Calcium Phosphate Nanoparticle Composite

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Publication Article, peer reviewed scientific
Title Tissue Reaction to a Novel Bone Substitute Material Fabricated With Biodegradable Polymer-Calcium Phosphate Nanoparticle Composite
Author Shimizu, Hideo ; Jinno, Yohei ; Ayukawa, Yasunori ; Atsuta, Ikiru ; Arahira, Takaaki ; Todo, Mitsugu ; Koyano, Kiyoshi
Date 2016
English abstract
Purpose: The aim of this study was to evaluate the effectiveness of a novel bone substitute material fabricated using a biodegradable polymer-calcium phosphate nanoparticle composite. Methods: Porous structured poly-L-lactic acid (PLLA) and hydroxyapatite (HA) nanoparticle composite, which was fabricated using solid-liquid phase separation and freeze-drying methods, was grafted into bone defects created in rat calvarium or tibia. Rats were killed 4 weeks after surgery, and histological analyses were performed to evaluate new bone formation. Results: Scanning electron microscopic observation showed the interconnecting pores within the material and the pore diameter was approximately 100 to 300 mm. HA nanoparticles were observed to be embedded into the PLLA beams. In the calvarial implantation model, abundant blood vessels and fibroblastic cells were observed penetrating into pores, and in the tibia model, newly formed bone was present around and within the composite. Conclusions: The PLLA-HA nanoparticle composite bone substitute developed in this study showed biocompatibility, elasticity, and operability and thus has potential as a novel bone substitute.
DOI https://doi.org/10.1097/ID.0000000000000447 (link to publisher's fulltext.)
Publisher Lippincott Williams & Wilkins
Host/Issue Implant Dentistry;5
Volume 25
ISSN 1056-6163
Language eng (iso)
Subject animal study
biocompatibility
organic material
Medicine
Research Subject Categories::MEDICINE
Handle http://hdl.handle.net/2043/25938 Permalink to this page
Link to publication in DiVA Find this research publication in DiVA.
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