Evaluation of the degradation behavior of resorbable metal implants for in vivo osteosynthesis by synchrotron radiation based x-ray tomography and histology

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Evaluation of the degradation behavior of resorbable metal implants for in vivo osteosynthesis by synchrotron radiation based x-ray tomography and histology

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Publication Paper in proceeding
Title Evaluation of the degradation behavior of resorbable metal implants for in vivo osteosynthesis by synchrotron radiation based x-ray tomography and histology
Author Galli, Silvia ; Hammel, Jörg U. ; Herzen, Julia ; Damm, Timo ; Jimbo, Ryo ; Beckmann, Felix ; Wennerberg, Ann ; Willumeit-Römer, Regine
Date 2016
English abstract
Magnesium(Mg)-alloys are promising candidates as temporary implants for orthopedic and cranio-facial applications. They can sustain tissues during healing, thanks to favorable mechanical properties, and then they slowly degrade into biocompatible products, avoiding the need of a second surgery for implant removal. They have the potential to benefit a vast number of patients, especially children and elderly patients. However, to be able to tailor their degradation to match the speed of tissue regeneration it is crucial to understand how they actually degrade in the living organism. We utilized high-resolution synchrotron-based tomography at the beamline P05 operated by HZG at the storage ring PETRA III at DESY to study the degradation of 3 novel Mg-alloys in rat bone and the consequent bone response. On three-dimensional reconstructions of the bone-implant explants we were able to follow the dynamic transformation that the materials underwent at different healing times and on the basis of absorption coefficients we could distinguish and quantify the amount of remaining implants, the corrosion layers and the new bone. This was a great advantage compared to laboratory CT, for which the limitation in contrast and in resolution made impossible to discriminate between original alloy, degradation products and bone, leading to inaccurate determination of the materials degradation rates. The same samples imaged by tomography were used for non-decalcified histology. The combination of histological and tomographical images provided new insight on the nature of the bone-to-implant interface and of the degradation products, which appeared to have great similarities to the host bone.
Conference
Developments in X-Ray Tomography X (29–31 August 2016 : San Diego, California)
DOI https://doi.org/10.1117/12.2237563 (link to publisher's fulltext.)
Publisher Spie - International Society For Optical Engineering
Host/Issue Developments in X-Ray Tomography X
Series/Issue Proceedings of SPIE - The International Society for Optical Engineering;9967
ISSN 0277-786X
ISBN 978-1-5106-0325-7
978-1-5106-0326-4
Language eng (iso)
Subject SR mu CT
tomography
magnesium
in situ
sample environment
degradation
corrosion
Sciences
Research Subject Categories::NATURAL SCIENCES
Handle http://hdl.handle.net/2043/25939 Permalink to this page
Link to publication in DiVA Find this research publication in DiVA.
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