Reversible Self-Assembled Monolayers (rSAMs) as Robust and Fluidic Lipid Bilayer Mimics

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Reversible Self-Assembled Monolayers (rSAMs) as Robust and Fluidic Lipid Bilayer Mimics

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Publication Article, peer reviewed scientific
Title Reversible Self-Assembled Monolayers (rSAMs) as Robust and Fluidic Lipid Bilayer Mimics
Author Yeung, Sing Yee ; Ederth, Thomas ; Pan, Guoqing ; Cicenaite, Judita ; Cárdenas, Marité ; Arnebrant, Thomas ; Sellergren, Börje
Date 2018
English abstract
Lipid bilayers, forming the outer barrier of cells, display a wide array of proteins and carbohydrates for modulating interfacial biological interactions. Formed by the spontaneous self-assembly of lipid molecules, these bilayers feature liquid crystalline order, while retaining a high degree of lateral mobility. Studies of these dynamic phenomena have been hampered by the fragility and instability of corresponding biomimetic cell membrane models. Here, we present the construct of a series of oligoethylene glycol-terminated reversible self-assembled monolayers (rSAMs) featuring lipid-bilayer-like fluidity, while retaining air and protein stability and resistance. These robust and ordered layers were prepared by simply immersing a carboxylic acid terminated self-assembled monolayer into 5-50 mu M aqueous omega-(4-ethylene glycol-phenoxy)-alpha-(4-amidinophenoxy)decane solutions. It is anticipated that this new class of robust and fluidic two-dimensional biomimetic surfaces will impact the design of rugged cell surface mimics and high-performance biosensors.
DOI https://doi.org/10.1021/acs.langmuir.8b00226 (link to publisher's fulltext.)
Publisher American Chemical Society
Host/Issue Langmuir;13
Volume 34
ISSN 0743-7463
Language eng (iso)
Subject Chemistry, Multidisciplinary
Chemistry, Physical
Materials Science, Multidisciplinary
Sciences
Research Subject Categories::NATURAL SCIENCES
Handle http://hdl.handle.net/2043/26640 Permalink to this page
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