Quantitative Phase Imaging for Label-Free Analysis of Cancer Cells-Focus on Digital Holographic Microscopy

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Quantitative Phase Imaging for Label-Free Analysis of Cancer Cells-Focus on Digital Holographic Microscopy

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Publication Article, review peer-reviewed scientific
Title Quantitative Phase Imaging for Label-Free Analysis of Cancer Cells-Focus on Digital Holographic Microscopy
Author El-Schich, Zahra ; Leida Mölder, Anna ; Gjörloff Wingren, Anette
Research Centre Biofilms - Research Center for Biointerfaces
Date 2018
English abstract
To understand complex biological processes, scientists must gain insight into the function of individual living cells. In contrast to the imaging of fixed cells, where a single snapshot of the cell’s life is retrieved, live-cell imaging allows investigation of the dynamic processes underlying the function and morphology of cells. Label-free imaging of living cells is advantageous since it is used without fluorescent probes and maintains an appropriate environment for cellular behavior, otherwise leading to phototoxicity and photo bleaching. Quantitative phase imaging (QPI) is an ideal method for studying live cell dynamics by providing data from noninvasive monitoring over arbitrary time scales. The effect of drugs on migration, proliferation, and apoptosis of cancer cells are emerging fields suitable for QPI analysis. In this review, we provide a current insight into QPI applied to cancer research.
DOI https://doi.org/10.3390/app8071027 (link to publisher's fulltext.)
Link http://www.mdpi.com/2076-3417/8/7/1027... (external link to publication)
Publisher MDPI
Host/Issue Applied Sciences;7
Volume 8
ISSN 2076-3417
Language eng (iso)
Subject microscopy
live cell imaging
quantitative phase imaging
digital holography
spatial light interference microscopy
cytometry
cancer
morphology
Sciences
Research Subject Categories::TECHNOLOGY
Handle http://hdl.handle.net/2043/26715 Permalink to this page
Link to publication in DiVA Find this research publication in DiVA.
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