Phytosphingosine Prevents the Formation of Young Salivary Biofilms in vitro

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Phytosphingosine Prevents the Formation of Young Salivary Biofilms in vitro

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Publication Article, peer reviewed scientific
Title Phytosphingosine Prevents the Formation of Young Salivary Biofilms in vitro
Author Bikker, Floris J. ; Hoogenkamp, Michel A. ; Malhaoui, Amine ; Nazmi, Kamran ; Neilands, Jessica ; Krom, Bastiaan P.
Date 2018
English abstract
Dental biofilms are formed in a multistep process that is initiated by the adhesion of oral bacteria to the dental hard surface. As dental biofilms are associated with oral diseases their control is necessary in order to maintain oral health. Recently, it was revealed that phytosphingosine (PHS)-treated hydroxyapatite discs showed anti-adhesive activity in a static in vitro biofilm model against Streptococcus mutans. The goal of the present study was to further unravel the anti-adhesive and anti-biofilm properties of PHS in both static and dynamic in vitro biofilm models against a full salivary inoculum. After 3 h under static conditions, bacterial adherence on PHS-treated cover glass slides was reduced by 60% compared to the untreated surface. After 6 and 24 h under static conditions, no significant differences in bacterial adherence were observed between PHS-treated and untreated cover glass slides. However, under dynamic conditions, i.e., the presence of shear forces, virtually no bacterial adherence was observed for up to 16 h on PHS-coated surfaces. Besides, PHS showed a strong bactericidal activity on salivary biofilms. Treatment of a 3- and 6-h statically grown biofilm resulted in a 99 and 94% reduction of viable cells, respectively, which was effectuated within minutes. In principle, these anti-adherence and anti-biofilm properties make PHS a promising candidate ingredient for use in oral care products aimed at oral microbial control. (C) 2017 S. Karger AG, Basel
DOI https://doi.org/10.1159/000480712 (link to publisher's fulltext.)
Publisher Karger
Host/Issue Caries Research;1-2
Volume 52
ISSN 0008-6568
Language eng (iso)
Subject Anti-adherence properties
Anti-biofilm properties
Phytosphingosine
Prevention
Saliva
Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/26841 Permalink to this page
Link to publication in DiVA Find this research publication in DiVA.
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