Amperometric monitoring of quercetin permeation through skin membranes

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Amperometric monitoring of quercetin permeation through skin membranes

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Publication Article, peer reviewed scientific
Title Amperometric monitoring of quercetin permeation through skin membranes
Author Rembiesa, Jadwiga ; Gari, Hala ; Engblom, Johan ; Ruzgas, Tautgirdas
Research Centre Biofilms - Research Center for Biointerfaces
Date 2015
English abstract
Transdermal delivery of quercetin (QR, 3,30,40,5,7-pentahydroxyflavone), a natural flavonoid with a considerable antioxidant capacity, is important for medical treatment of, e.g., skin disorders. QR permeability through skin is low, which, at the same time, makes the monitoring of percutaneous QR penetration difficult. The objective of this study was to assess an electrochemical method for monitoring QR penetration through skin membranes. An electrode was covered with the membrane, exposed to QR solution, and electrode current was measured. The registered current was due to electro-oxidation of QR penetrating the membrane. Exploiting strict current-QR flux relationships diffusion coefficient, D, of QR in skin and dialysis membranes was calculated. The D values were strongly dependent on the theoretical model and parameters assumed in the processing of the amperometric data. The highest values of D were in the range of 1.6-6.1 x 10(-7) cm(2)/s. This was reached only for skin membranes pretreated with buffer-ethanol mixture for more than 24 h. QR solutions containing penetration enhancers, ethanol and L-menthol, definitely increased D values. The results demonstrate that electrochemical setup gives a possibility to assess penetration characteristics as well as enables monitoring of penetration dynamics, which is more difficult by traditional methods using Franz cells. (C) 2015 Elsevier B.V. All rights reserved.
DOI https://doi.org/10.1016/j.ijpharm.2015.10.073 (link to publisher's fulltext.)
Publisher Elsevier
Host/Issue International Journal of Pharmaceutics;2
Volume 496
ISSN 0378-5173
Pages 636-643
Language eng (iso)
Subject Quercetin
Flavonoids
Electrochemistry
Skin permeation
Penetration enhancers
Diffusion coefficient
Medicine
Research Subject Categories::PHARMACY
Handle http://hdl.handle.net/2043/27375 Permalink to this page
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