Human Leucocyte Antigen Profile and Transmission of Mutans Streptococci in Mother-Child Pairs

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Human Leucocyte Antigen Profile and Transmission of Mutans Streptococci in Mother-Child Pairs

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Publication Article, peer reviewed scientific
Title Human Leucocyte Antigen Profile and Transmission of Mutans Streptococci in Mother-Child Pairs
Author Wallengren, Marie Louise ; Hedström, Kristin ; Zbroszyk, Katarzyna ; Hamberg, Kristina
Date 2015
English abstract
Purpose: To investigate possible association between the transmission of mutans streptococci and sharing the immune system component Human Leucocyte Antigen (HLA) class II in mother-child pairs. Material and Methods: Plaque samples from 43 mother-child pairs were cultivated and screened for mutans streptococci. In 14 pairs where both mother and child harboured the bacteria, the strains were genotyped by Random Amplified Polymorphic DNA and samples were run on PAGE gels. Analysis of genetic identity between mother and child strains was performed with help of software and Dice similarity index. The distribution of HLA of serogroup DR4 (HLA DR4) was studied in relation to maternal transmission and mutans streptococci colonisation in children. The study hypothesis was that in pairs where both mother and child were HLA DR4 positive, transmission of mutans streptococci was more likely. Results: No correlation between the presence of HLA DR4 in mother and child and maternal transmission of mutans streptococci was established. However, the results showed no linkage between mutans streptococci colonisation and HLA DR 4. Of 15 children with mutans streptococci, 12 were HLA DR4 positive. Conclusion: The result suggests that presence of HLA DR4 could be a predisposing factor for colonisation with mutans streptococci in children.
DOI https://doi.org/10.3290/j.ohpd.a34369 (link to publisher's fulltext.)
Publisher Quintessence
Host/Issue Oral Health & Preventive Dentistry;5
Volume 13
ISSN 1602-1622
Pages 8
Page 449-456
Language eng (iso)
Subject colonisation
HLA
mother-child pair
mutans streptococci
transmission
Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/27399 Permalink to this page
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