Circulating CD40(+) and CD86(+) B Cell Subsets Demonstrate Opposing Associations With Risk of Stroke

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Circulating CD40(+) and CD86(+) B Cell Subsets Demonstrate Opposing Associations With Risk of Stroke

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Publication Article, peer reviewed scientific
Title Circulating CD40(+) and CD86(+) B Cell Subsets Demonstrate Opposing Associations With Risk of Stroke
Author Mantani, Polyxeni T. ; Ljungcrantz, Irena ; Andersson, Linda ; Alm, Ragnar ; Hedblad, Bo ; Björkbacka, Harry ; Nilsson, Jan ; Nordin Fredrikson, Gunilla
Date 2014
English abstract
Objective-Accumulating evidence shows that immune cells play an important role in atherosclerosis. Most attention has focused on the role of different T cell subsets, whereas the possible involvement of B cells has been less studied. In this study, we assessed the association of 2 different B cell subsets, CD19(+)CD40(+) and CD19(+)CD86(+) B cells, with risk for development of acute cardiovascular events. Approach and Results-The prospective study included 700 subjects randomly selected from the cardiovascular cohort of the Malmo Diet and Cancer study. Mononuclear leukocytes, stored at -140 degrees C at the baseline investigation in 1991-1994, were thawed and B cell subsets analyzed by flow cytometry. Cytokine release from CD3/CD28-stimulated mononuclear leukocytes was measured with multiplex ELISA. Baseline carotid intima-media thickness and stenosis were assessed by ultrasonography, and clinical events were monitored through validated national registers during a median/mean follow-up time of 15 years. The subjects in the highest tertile of CD19(+)CD40(+) B cells had a significantly lower risk of incident stroke after adjustment for other risk factors. In contrast, CD19(+)CD86(+) B cells were associated with higher risk for development of a stroke event and increased release of proinflammatory cytokines from mononuclear leukocytes. Conclusions-These observations provide evidence for an involvement of B cells in the incidence of stroke and suggest that both pathogenic and protective B cell subsets exist.
DOI https://doi.org/10.1161/ATVBAHA.113.302667 (link to publisher's fulltext.)
Publisher Lippincott Williams & Wilkins
Host/Issue Arteriosclerosis, Thrombosis, and Vascular Biology;1
Volume 34
ISSN 1079-5642
Pages 8
Page 211-218
Language eng (iso)
Subject B-lymphocyte subsets
carotid artery diseases
prospective studies
stroke
Medicine
Research Subject Categories::MEDICINE
Handle http://hdl.handle.net/2043/27417 Permalink to this page
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