The Effect of Brain-Derived Neurotrophic Factor on Periodontal Furcation Defects

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The Effect of Brain-Derived Neurotrophic Factor on Periodontal Furcation Defects

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Publication Article, peer reviewed scientific
Title The Effect of Brain-Derived Neurotrophic Factor on Periodontal Furcation Defects
Author Jimbo, Ryo ; Tovar, Nick ; Janal, Malvin N. ; Mousa, Ramy ; Marin, Charles ; Yoo, Daniel ; Teixeira, Hellen S. ; Anchieta, Rodolfo B. ; Bonfante, Estevam A. ; Konishi, Akihiro ; Takeda, Katsuhiro ; Kurihara, Hidemi ; Coelho, Paulo G.
Date 2014
English abstract
This study aimed to observe the regenerative effect of brain-derived neurotrophic factor (BDNF) in a non-human primate furcation defect model. Class II furcation defects were created in the first and second molars of 8 non-human primates to simulate a clinical situation. The defect was filled with either, Group A: BDNF (500 mu g/ml) in high-molecular weight-hyaluronic acid (HMW-HA), Group B: BDNF (50 mu g/ml) in HMW-HA, Group C: HMW-HA acid only, Group D: empty defect, or Group E: BDNF (500 mu g/ml) in saline. The healing status for all groups was observed at different time-points with micro computed tomography. The animals were euthanized after 11 weeks, and the tooth-bone specimens were subjected to histologic processing. The results showed that all groups seemed to successfully regenerate the alveolar buccal bone, however, only Group A regenerated the entire periodontal tissue, i.e., alveolar bone, cementum and periodontal ligament. It is suggested that the use of BDNF in combination with a scaffold such as the hyaluronic acid in periodontal furcation defects may be an effective treatment option.
DOI https://doi.org/10.1371/journal.pone.0084845 (link to publisher's fulltext.)
Link https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084845 .Icon
Publisher Public Library of Science
Host/Issue PLoS ONE;1
Volume 9
ISSN 1932-6203
Language eng (iso)
Subject Multidisciplinary Sciences
Sciences
Research Subject Categories::NATURAL SCIENCES
Handle http://hdl.handle.net/2043/27474 Permalink to this page
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