Bone Immune Response to Materials, Part II : Copper and Polyetheretherketone (PEEK) Compared to Titanium at 10 and 28 Days in Rabbit Tibia

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Bone Immune Response to Materials, Part II : Copper and Polyetheretherketone (PEEK) Compared to Titanium at 10 and 28 Days in Rabbit Tibia

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Publication Article, peer reviewed scientific
Title Bone Immune Response to Materials, Part II : Copper and Polyetheretherketone (PEEK) Compared to Titanium at 10 and 28 Days in Rabbit Tibia
Author Trindade, Ricardo ; Albrektsson, Tomas ; Galli, Silvia ; Prgomet, Zdenka ; Tengvall, Pentti ; Wennerberg, Ann
Research Centre Biofilms - Research Center for Biointerfaces
Date 2019
English abstract
Abstract: Osseointegration is likely the result of an immunologically driven bone reaction to materials such as titanium. Osseointegration has resulted in the clinical possibility to anchor oral implants in jaw bone tissue. However, the mechanisms behind bony anchorage are not fully understood and complications over a longer period of time have been reported. The current study aims at exploring possible differences between copper (Cu) and polyetheretherketone (PEEK) materials that do not osseointegrate, with osseointegrating cp titanium as control. The implants were placed in rabbit tibia and selected immune markers were evaluated at 10 and 28 days of follow-up. Cu and PEEK demonstrated at both time points a higher immune activation than cp titanium. Cu demonstrated distance osteogenesis due to a maintained proinflammatory environment over time, and PEEK failed to osseointegrate due to an immunologically defined preferential adipose tissue formation on its surface. The here presented results suggest the description of two different mechanisms for failed osseointegration, both of which are correlated to the immune system.
DOI https://doi.org/10.3390/jcm8060814 (link to publisher's fulltext.)
Link https://doi.org/10.3390/jcm8060814 .Icon
Publisher MDPI
Host/Issue Journal of Clinical Medicine;6
Volume 8
ISSN 2077-0383
Language eng (iso)
Subject biomaterial
bone
osseointegration
immune
implant
healing
titanium
PEEK
Cu
Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/28805 Permalink to this page
Link to publication in DiVA Find this research publication in DiVA (n/a for student publ.)
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