Dehydration affects drug transport over nasal mucosa

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Dehydration affects drug transport over nasal mucosa

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Publication Article, peer reviewed scientific
Title Dehydration affects drug transport over nasal mucosa
Author Wahlgren, Marie ; Rembratt-Svensson, Birgitta ; Daftani, Ameena ; Falkman, Peter ; Wollmer, Per ; Engblom, Johan ; Ali, Abdullah
Research Centre Biofilms - Research Center for Biointerfaces
Date 2019
English abstract
Formulations for nasal drug delivery often rely on water sorption to adhere to the mucosa, which also causes a higher water gradient over the tissue and subsequent dehydration. The primary aim of this study was therefore to evaluate mucosal response to dehydration and resolve the hypothesis that mucoadhesion achieved through water sorption could also be a constraint for drug absorption via the nasal route. The effect of altering water activity of the vehicle on Xylometazoline HCl and Cr-EDTA uptake was studied separately using flow through diffusion cells and excised porcine mucosa. We have shown that a modest increase in the water gradient over mucosa induces a substantial decrease in drug uptake for both Xylometazoline HCl and Cr-EDTA. A similar result was obtained when comparing two different vehicles on the market; Nasoferm (Nordic Drugs, Sweden) and BLOX4 (Bioglan, Sweden). Mucoadhesion based on water sorption can slow down drug uptake in the nasal cavity. However, a clinical study is required to determine whether prolonged duration of the vehicle or preventing dehydration of the mucosa is the most important factor for improving bioavailability.
DOI https://doi.org/10.1080/10717544.2019.1650848 (link to publisher's fulltext.)
Link http://dx.doi.org/10.1080/10717544.2019.1650848 .Icon
Publisher Taylor & Francis
Host/Issue Drug delivery;1
Volume 26
ISSN 1521-0464
Language eng (iso)
Subject Mucoadhesion
dehydration
drug transport
nasal drug delivery
water activity
Sciences
Research Subject Categories::PHARMACY
Note Drug Deliv
Handle http://hdl.handle.net/2043/29688 Permalink to this page
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