Hybrid coating of alginate microbeads based on protein-biopolymer multilayers for encapsulation of probiotics

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Hybrid coating of alginate microbeads based on protein-biopolymer multilayers for encapsulation of probiotics

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Publication Article, peer reviewed scientific
Title Hybrid coating of alginate microbeads based on protein-biopolymer multilayers for encapsulation of probiotics
Author Falco, Cigdem Yucel ; Amadei, Federico ; Dhayal, Surender K. ; Cárdenas, Marité ; Tanaka, Motomu ; Risbo, Jens
Research Centre Biofilms - Research Center for Biointerfaces
Date 2019
English abstract
A hybrid coating based on multilayers of proteins and biopolymers was developed to enhance the protection performance of alginate microbeads against acidic conditions for delivery of probiotics (Lactobacillus rhamnosus GG). Zeta potential measurements and quartz crystal microbalance with dissipation confirmed layer-by-layer deposition of protein-polymer layers. The stability of protein-based coatings during simulated gastric fluid (SGF) treatment was monitored by microscopy. Protein-coated microbeads were partially dismantled, whereas polymer-coated microbeads were intact after a sequential treatment in simulated gastric and intestinal fluids. This suggests that hybrid formulation offers an advantage over the coatings based on biopolymer multilayers in terms of better release of bacteria. Uncoated alginate microbeads completely dissolved and could not protect bacteria after SGF treatment whereas microbeads with hybrid coating showed increased physical stability and a modest decrease of culturability of 3.8 log units. Therefore, this work provides a concept for future protein-based hybrid coatings for bacterial delivery systems.
DOI https://doi.org/10.1002/btpr.2806 (link to publisher's fulltext.)
Publisher Wiley
Host/Issue Biotechnology Progress;3
Volume 35
ISSN 8756-7938
Language eng (iso)
Subject alginate
chitosan
lactoferrin
layer-by-layer
microencapsulation of probiotics
Sciences
Research Subject Categories::NATURAL SCIENCES
Handle http://hdl.handle.net/2043/29897 Permalink to this page
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