Aseptic Ligatures Induce Marginal Peri-Implant Bone Loss-An 8-Week Trial in Rabbits

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Aseptic Ligatures Induce Marginal Peri-Implant Bone Loss-An 8-Week Trial in Rabbits

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Publication Article, peer reviewed scientific
Title Aseptic Ligatures Induce Marginal Peri-Implant Bone Loss-An 8-Week Trial in Rabbits
Author Reinedahl, David ; Tengvall, Pentti ; Johansson, Carina B ; Hammarström Johansson, Petra ; Galli, Silvia ; Albrektsson, Tomas ; Wennerberg, Ann
Research Centre Biofilms - Research Center for Biointerfaces
Date 2019
English abstract
The clinical value of ligature-induced experimental peri-implantitis studies has been questioned due to the artificial nature of the model. Despite repeated claims that ligatures of silk, cotton and other materials may not induce bone resorption by themselves; a recent review showed that the tissue reaction toward them has not been investigated. Hence, the current study aimed to explore the hard and soft tissue reactions toward commonly used ligature materials. A total of 60 dental implants were inserted into the femur ( = 20) and tibia ( = 40) of 10 rabbits. The femoral implants were ligated with sterile 3-0 braided silk in one leg and sterile cotton retraction chord in the other leg. The tibial implants were ligated with silk or left as non-ligated controls. All wounds were closed in layers. After a healing time of 8 weeks, femoral (silk versus cotton) and proximal tibial (silk versus non-ligated control) implants were investigated histologically. Distal tibial (silk versus non-ligated control) implants were investigated with real time polymerase chain reaction (qPCR). The distance from the implant-top to first bone contact point was longer for silk ligated implants compared to non-ligated controls ( = 0.007), but did not vary between cotton and silk. The ligatures triggered an immunological reaction with cell infiltrates in close contact with the ligature materials, adjacent soft tissue encapsulation and bone resorption. qPCR further demonstrated an upregulated immune response toward the silk ligatures compared to non-ligated controls. Silk and cotton ligatures provoke foreign body reactions of soft tissue encapsulation type and bone resorption around implants in the absence of plaque.
DOI https://doi.org/10.3390/jcm8081248 (link to publisher's fulltext.)
Link https://www.mdpi.com/2077-0383/8/8/1248 .Icon
Publisher MDPI
Host/Issue Journal of clinical medicine;8
Volume 8
ISSN 2077-0383
Language eng (iso)
Subject aseptic loosening
dental implant
ligature induced peri-implantitis
marginal bone loss
osseointegration
Medicine
Research Subject Categories::ODONTOLOGY
Note J Clin Med
Handle http://hdl.handle.net/2043/30038 Permalink to this page
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