Cohort profile: the West Sweden Asthma Study (WSAS) : a multidisciplinary population-based longitudinal study of asthma, allergy and respiratory conditions in adults.

DSpace Repository

Cohort profile: the West Sweden Asthma Study (WSAS) : a multidisciplinary population-based longitudinal study of asthma, allergy and respiratory conditions in adults.

Overview

Detailed record

dc.contributor.author Nwaru, Bright I sv
dc.contributor.author Ekerljung, Linda sv
dc.contributor.author Rådinger, Madeleine sv
dc.contributor.author Bjerg, Anders sv
dc.contributor.author Mincheva, Roxana sv
dc.contributor.author Malmhäll, Carina sv
dc.contributor.author Wennergren, Göran sv
dc.contributor.author Lotvall, Jan sv
dc.contributor.author Lundbäck, Bo sv
dc.contributor.author Axelsson, Malin en_US
dc.date.accessioned 2019-10-01T13:25:00Z
dc.date.available 2019-10-01T13:25:00Z
dc.date.issued 2019 en_US
dc.identifier.issn 2044-6055 en_US
dc.identifier.uri http://hdl.handle.net/2043/30063
dc.description.abstract PURPOSE: The West Sweden Asthma Study (WSAS) is a population-representative longitudinal study established to: (1) generate data on prevalence trends, incidence and remission of asthma, allergy and respiratory conditions, (2) elucidate on the risk and prognostic factors associated with these diseases, (3) characterise clinically relevant phenotypes of these diseases and (4) catalyse relevant mechanistic, genomic, genetic and translational investigations. PARTICIPANTS: WSAS comprised of randomly selected individuals aged 16 to 75 years who are followed up longitudinally. The first stage involved a questionnaire survey (>42 000 participants) and was undertaken in 2008 and 2016. A random sample (about 8000) of participants in the initial survey undergoes extensive clinical investigations every 8 to 10 years (first investigations in 2009 to 2012, second wave currently ongoing). Measurements undertaken at the clinical investigations involve structured interviews, self-completed questionnaire on personality traits, physical measurements and extensive biological samples. FINDINGS TO DATE: Some of our key findings have shown a 54% increase in the use of asthma medications between the 1990s and 2000s, primarily driven by a five-fold increase in the use of inhaled corticosteroids. About 36% of asthmatics expressed at least one sign of severe asthma indicator, with differential lung performance, inflammation and allergic sensitisation among asthmatics with different signs of severe asthma. Multi-symptom asthmatics were at greater risk of having indicators of severe asthma. In all adults, being raised on a farm was associated with a decreased risk of allergic sensitisation, rhinitis and eczema, but not asthma. However, among adolescents (ie, those 16 to 20 years of age), being raised on a farm decreased the risk of asthma. Personality traits were associated with both beliefs of asthma medication and adherence to treatment. FUTURE PLANS: Follow-up of the cohort is being undertaken every 8 to 10 years. The repeated clinical examinations will take place in 2019 to 2022. The cohort data are currently being linked to routine Swedish healthcare registers for a continuous follow-up. Mechanistic, genomic, genetic and translational investigations are ongoing. en_US
dc.language.iso eng en_US
dc.publisher BMJ en_US
dc.subject.classification Medicine en_US
dc.title Cohort profile: the West Sweden Asthma Study (WSAS) : a multidisciplinary population-based longitudinal study of asthma, allergy and respiratory conditions in adults. en_US
dc.type Article, peer reviewed scientific en_US
dc.contributor.department Malmö University. Faculty of Health and Society
dc.contributor.department Malmö University. Care Science (VV)
dc.identifier.doi 10.1136/bmjopen-2018-027808 en_US
dc.subject.srsc Research Subject Categories::MEDICINE en_US
dc.relation.ispartofpublication BMJ Open;6
dc.relation.ispartofpublicationvolume 9 en_US
dc.description.authorversion No en_US
dc.identifier.pmid 31221886
dcterms.identifier.OAurl https://bmjopen.bmj.com/content/9/6/e027808 en_US
dc.format.artNo e027808 en_US
 Find Full text Files for download
Icon

This item appears in the following Collection(s)

Overview

Search


Browse

My Account

Statistics