Polyphenol-hydrogen peroxide reactions in skin : In vitro model relevant to study ROS reactions at inflammation

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Polyphenol-hydrogen peroxide reactions in skin : In vitro model relevant to study ROS reactions at inflammation

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dc.contributor.author Eskandari, Mahboubeh
dc.contributor.author Rembiesa, Jadwiga
dc.contributor.author Startaite, Lauryna
dc.contributor.author Holefors, Anna
dc.contributor.author Valanciute, Audrone
dc.contributor.author Faridbod, Farnoush
dc.contributor.author Ganjali, Mohammad Reza
dc.contributor.author Engblom, Johan
dc.contributor.author Ruzgas, Tautgirdas
dc.date.accessioned 2019-10-04T09:19:06Z
dc.date.available 2019-10-04T09:19:06Z
dc.date.issued 2019 en_US
dc.identifier.issn 0003-2670 en_US
dc.identifier.uri http://hdl.handle.net/2043/30126
dc.description.abstract Antioxidants are important to protect and maintain biological barriers, such as the skin. Antioxidant effects are often assessed using clinical trials, however these tests are costly and time consuming. In this work we introduce a skin membrane-covered oxygen electrode (SCOE) as an in vitro tool for monitoring H2O2 and antioxidant reactions in skin. The SCOE gives amperometric response to H2O2 concentrations down to 0.05 mM. More importantly, the electrode allows measurements of polyphenol penetration and reaction with H2O2 in skin. Measurements with SCOE show that lipophilic polyphenols such as quercetin, piceatannol, resveratrol, and plant extract from Plantago major impose their antioxidant effect in skin within 2-20 min. Rutin is however too hydrophilic to penetrate into stratum corneum and therefore cannot deliver its antioxidant effect during similar time interval. The measurements are interpreted considering polyphenol partition-penetration through stratum corneum and the reaction with the H2O2-catalase system in the skin. The contribution of other enzymes will be addressed in the future. (C) 2019 Elsevier B.V. All rights reserved. en_US
dc.format.extent 7 en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.subject Skin en_US
dc.subject Oxygen electrode en_US
dc.subject Antioxidants en_US
dc.subject Reactive oxygen species en_US
dc.subject Polyphenols en_US
dc.subject Inflammation en_US
dc.subject.classification Sciences en_US
dc.title Polyphenol-hydrogen peroxide reactions in skin : In vitro model relevant to study ROS reactions at inflammation en_US
dc.type Article, peer reviewed scientific en_US
dc.contributor.department Malmö University. Faculty of Health and Society
dc.contributor.department Malmö University. Biomedical Sciences (BMV)
dc.identifier.doi 10.1016/j.aca.2019.05.032 en_US
dc.subject.srsc Research Subject Categories::NATURAL SCIENCES en_US
dc.relation.ispartofpublication Analytica Chimica Acta;
dc.relation.ispartofpublicationvolume 1075 en_US
dc.description.authorversion No en_US
dc.identifier.isiid 000470820800008
dc.contributor.centre Malmö University. Biofilms - Research Center for Biointerfaces en_US
dc.identifier.pmid 31196427
dc.format.ePage 97 en_US
dc.format.sPage 91 en_US
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