Time-resolved small-angle neutron scattering as a probe for the dynamics of lipid exchange between human lipoproteins and naturally derived membranes

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Time-resolved small-angle neutron scattering as a probe for the dynamics of lipid exchange between human lipoproteins and naturally derived membranes

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dc.contributor.author Maric, Selma
dc.contributor.author Lind, Tania Kjellerup
dc.contributor.author Raida, Manfred Roman
dc.contributor.author Bengtsson, Eva
dc.contributor.author Fredrikson, Gunilla Nordin
dc.contributor.author Rogers, Sarah
dc.contributor.author Moulin, Martine
dc.contributor.author Haertlein, Michael
dc.contributor.author Forsyth, V. Trevor
dc.contributor.author Wenk, Markus R.
dc.contributor.author Pomorski, Thomas Guenther
dc.contributor.author Arnebrant, Thomas
dc.contributor.author Lund, Reidar
dc.contributor.author Cardenas, Marite
dc.date.accessioned 2019-10-07T11:15:32Z
dc.date.available 2019-10-07T11:15:32Z
dc.date.issued 2019 en_US
dc.identifier.issn 2045-2322 en_US
dc.identifier.uri http://hdl.handle.net/2043/30138
dc.description.abstract Atherosclerosis is the main killer in the western world. Today's clinical markers include the total level of cholesterol and high-/low-density lipoproteins, which often fails to accurately predict the disease. The relationship between the lipid exchange capacity and lipoprotein structure should explain the extent by which they release or accept lipid cargo and should relate to the risk for developing atherosclerosis. Here, small-angle neutron scattering and tailored deuteration have been used to follow the molecular lipid exchange between human lipoprotein particles and cellular membrane mimics made of natural, "neutron invisible" phosphatidylcholines. We show that lipid exchange occurs via two different processes that include lipid transfer via collision and upon direct particle tethering to the membrane, and that high-density lipoprotein excels at exchanging the human-like unsaturated phosphatidylcholine. By mapping the specific lipid content and level of glycation/oxidation, the mode of action of specific lipoproteins can now be deciphered. This information can prove important for the development of improved diagnostic tools and in the treatment of atherosclerosis. en_US
dc.format.extent 14 en_US
dc.language.iso eng en_US
dc.publisher Nature Publishing Group en_US
dc.subject Multidisciplinary Sciences en_US
dc.subject.classification Sciences en_US
dc.title Time-resolved small-angle neutron scattering as a probe for the dynamics of lipid exchange between human lipoproteins and naturally derived membranes en_US
dc.type Article, peer reviewed scientific en_US
dc.contributor.department Malmö University. Faculty of Health and Society
dc.contributor.department Malmö University. Biomedical Sciences (BMV)
dc.identifier.doi 10.1038/s41598-019-43713-6 en_US
dc.subject.srsc Research Subject Categories::NATURAL SCIENCES en_US
dc.relation.ispartofpublication Scientific Reports;1
dc.relation.ispartofpublicationvolume 9 en_US
dc.description.authorversion No en_US
dc.identifier.isiid 000468281500021
dc.identifier.pmid 31110185
dcterms.identifier.OAurl https://doi.org/10.1038/s41598-019-43713-6 en_US
dc.format.artNo 7591 en_US
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