Periodontal Health and Oral Microbiota in Patients with Rheumatoid Arthritis

DSpace Repository

Periodontal Health and Oral Microbiota in Patients with Rheumatoid Arthritis

Details

Files for download
Icon
Overview of item record
Publication Article, peer reviewed scientific
Title Periodontal Health and Oral Microbiota in Patients with Rheumatoid Arthritis
Author Eriksson, Kaja ; Fei, Guozhong ; Lundmark, Anna ; Benchimol, Daniel ; Lee, Linkiat ; Hu, Yue O. O. ; Kats, Anna ; Saevarsdottir, Saedis ; Catrina, Anca Irinel ; Klinge, Björn ; Andersson, Anders F. ; Klareskog, Lars ; Lundberg, Karin ; Jansson, Leif ; Yucel-Lindberg, Tulay
Date 2019
English abstract
This study aimed to investigate the periodontal health of patients with established rheumatoid arthritis (RA) in relation to oral microbiota, systemic and oral inflammatory mediators, and RA disease activity. Forty patients underwent full-mouth dental/periodontal and rheumatological examination, including collection of blood, saliva, gingival crevicular fluid (GCF) and subgingival plaque. Composition of plaque and saliva microbiota were analysed using 16S rRNA sequencing and levels of inflammatory mediators by multiplex-immunoassay. The majority of the patients (75%) had moderate or severe periodontitis and the rest had no/mild periodontitis. Anti-citrullinated protein antibody (ACPA) positivity was significantly more frequent in the moderate/severe periodontitis (86%) compared to the no/mild group (50%). No significance between groups was observed for RA disease duration or activity, or type of medication. Levels of sCD30/TNFRSF8, IFN-2, IL-19, IL-26, MMP-1, gp130/sIL-6R ss, and sTNF-R1 were significantly higher in serum or GCF, and April/TNFSF13 was significantly higher in serum and saliva samples in moderate/severe periodontitis. The microbial composition in plaque also differed significantly between the two groups. In conclusion, the majority of RA patients had moderate/severe periodontitis and that this severe form of the disease was significantly associated with ACPA positivity, an altered subgingival microbial profile, and increased levels of systemic and oral inflammatory mediators.
DOI https://doi.org/10.3390/jcm8050630 (link to publisher's fulltext.)
Link https://www.mdpi.com/2077-0383/8/5/630 .Icon
Publisher MDPI
Host/Issue Journal of Clinical Medicine;5
Volume 8
ISSN 2077-0383
Language eng (iso)
Subject rheumatoid arthritis
periodontitis
periodontal disease
anti-citrullinated protein autoantibodies
rheumatoid factor
smoking
medication
Porphyromonas gingivalis
Medicine
Research Subject Categories::MEDICINE
Handle http://hdl.handle.net/2043/30141 Permalink to this page
Facebook

This item appears in the following Collection(s)

Details

Search


Browse

My Account

Statistics