Periodontal Health and Oral Microbiota in Patients with Rheumatoid Arthritis

DSpace Repository

Periodontal Health and Oral Microbiota in Patients with Rheumatoid Arthritis

Overview

Detailed record

dc.contributor.author Eriksson, Kaja
dc.contributor.author Fei, Guozhong
dc.contributor.author Lundmark, Anna
dc.contributor.author Benchimol, Daniel
dc.contributor.author Lee, Linkiat
dc.contributor.author Hu, Yue O. O.
dc.contributor.author Kats, Anna
dc.contributor.author Saevarsdottir, Saedis
dc.contributor.author Catrina, Anca Irinel
dc.contributor.author Klinge, Björn
dc.contributor.author Andersson, Anders F.
dc.contributor.author Klareskog, Lars
dc.contributor.author Lundberg, Karin
dc.contributor.author Jansson, Leif
dc.contributor.author Yucel-Lindberg, Tulay
dc.date.accessioned 2019-10-07T11:35:30Z
dc.date.available 2019-10-07T11:35:30Z
dc.date.issued 2019 en_US
dc.identifier.issn 2077-0383 en_US
dc.identifier.uri http://hdl.handle.net/2043/30141
dc.description.abstract This study aimed to investigate the periodontal health of patients with established rheumatoid arthritis (RA) in relation to oral microbiota, systemic and oral inflammatory mediators, and RA disease activity. Forty patients underwent full-mouth dental/periodontal and rheumatological examination, including collection of blood, saliva, gingival crevicular fluid (GCF) and subgingival plaque. Composition of plaque and saliva microbiota were analysed using 16S rRNA sequencing and levels of inflammatory mediators by multiplex-immunoassay. The majority of the patients (75%) had moderate or severe periodontitis and the rest had no/mild periodontitis. Anti-citrullinated protein antibody (ACPA) positivity was significantly more frequent in the moderate/severe periodontitis (86%) compared to the no/mild group (50%). No significance between groups was observed for RA disease duration or activity, or type of medication. Levels of sCD30/TNFRSF8, IFN-2, IL-19, IL-26, MMP-1, gp130/sIL-6R ss, and sTNF-R1 were significantly higher in serum or GCF, and April/TNFSF13 was significantly higher in serum and saliva samples in moderate/severe periodontitis. The microbial composition in plaque also differed significantly between the two groups. In conclusion, the majority of RA patients had moderate/severe periodontitis and that this severe form of the disease was significantly associated with ACPA positivity, an altered subgingival microbial profile, and increased levels of systemic and oral inflammatory mediators. en_US
dc.format.extent 18 en_US
dc.language.iso eng en_US
dc.publisher MDPI en_US
dc.subject rheumatoid arthritis en_US
dc.subject periodontitis en_US
dc.subject periodontal disease en_US
dc.subject anti-citrullinated protein autoantibodies en_US
dc.subject rheumatoid factor en_US
dc.subject smoking en_US
dc.subject medication en_US
dc.subject Porphyromonas gingivalis en_US
dc.subject.classification Medicine en_US
dc.title Periodontal Health and Oral Microbiota in Patients with Rheumatoid Arthritis en_US
dc.type Article, peer reviewed scientific en_US
dc.contributor.department Malmö University. Faculty of Odontology
dc.identifier.doi 10.3390/jcm8050630 en_US
dc.subject.srsc Research Subject Categories::MEDICINE en_US
dc.relation.ispartofpublication Journal of Clinical Medicine;5
dc.relation.ispartofpublicationvolume 8 en_US
dc.description.authorversion No en_US
dc.identifier.isiid 000470992500065
dc.identifier.pmid 31072030
dcterms.identifier.OAurl https://doi.org/10.3390/jcm8050630 en_US
dc.format.artNo 630 en_US
 Find Full text Files for download
Icon

This item appears in the following Collection(s)

Overview

Search


Browse

My Account

Statistics