PRGF as adjunct to DBB in maxillary sinus floor augmentation : histological results of a pilot split-mouth study

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PRGF as adjunct to DBB in maxillary sinus floor augmentation : histological results of a pilot split-mouth study

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Publication Article, peer reviewed scientific
Title PRGF as adjunct to DBB in maxillary sinus floor augmentation : histological results of a pilot split-mouth study
Author Batas, Leonidas ; Tsalikis, Lazaros ; Stavropoulos, Andreas
Date 2019
English abstract
Background: Various technologies of autologous blood concentrates are currently evaluated for their potential to enhance bone formation. Aim: To report on the histological outcome of maxillary sinus floor augmentation (MSFA) with deproteinized bovine bone (DBB) in combination with chair-side prepared autologous platelet-rich growth factor (PRGF), in comparison to that with DBB alone. Materials and methods: Six partially edentulous patients with 3-mm residual bone height bilaterally in the posterior maxilla were subjected to MSFA with the lateral window technique, using DBB in combination with PRGF (PRGF System1 Vitoria, Spain) on one side or DBB alone on the contralateral side. Cylindrical biopsies from the augmented sinuses were collected during implant installation, ca. 6months post-MSFA, and subjected to non-decalcified histological and histomorphometric evaluation. Results: The collected biopsies varied in length (range 3.5-9.9mm); consequently, the portion of the biopsy representing augmented tissues also varied (range 2.3-14.6mm(2)). New bone formation with a trabecular appearance and numerous DBB particles in contact with the new bone or with loose connective tissue were observed. No differences in the relative volumes of bone formation were found in sinuses augmented with DBB+PRGF or DBB alone 6months after MSFA (35.68.26mm and 37.8 +/- 3.15mm, respectively). Conclusion and clinical implications: In conclusion, based on these preliminary results, PRGF as adjunct to DBB for MSFA, except from improved handling during the operation, does not appear to enhance nor interfere with bone formation inside the human sinus 6months after MSFA, compared with the use of DBB alone.
DOI https://doi.org/10.1186/s40729-019-0166-6 (link to publisher's fulltext.)
Link https://journalimplantdent.springeropen.com/articles/10.1186/s40729-019-0166-6 .Icon
Publisher Springer
Host/Issue International Journal of Implant Dentistry;1
Volume 5
ISSN 2198-4034
Language eng (iso)
Subject PRGF
Deproteinized bovine bone
Sinus elevation
Histology
Humans
Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/30154 Permalink to this page
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