Oscillometry in Chronic Obstructive Lung Disease : In vitro and in vivo evaluation of the impulse oscillometry and tremoflo devices

DSpace Repository

Oscillometry in Chronic Obstructive Lung Disease : In vitro and in vivo evaluation of the impulse oscillometry and tremoflo devices

Overview

Detailed record

dc.contributor.author Lundblad, Lennart K. A.
dc.contributor.author Miletic, Ruzica
dc.contributor.author Piitulainen, Eeva
dc.contributor.author Wollmer, Per
dc.date.accessioned 2019-10-14T13:35:54Z
dc.date.available 2019-10-14T13:35:54Z
dc.date.issued 2019 en_US
dc.identifier.issn 2045-2322 en_US
dc.identifier.uri http://hdl.handle.net/2043/30215
dc.description.abstract Impedance, or oscillometry, measurements of the respiratory system can generate information about the function of the respiratory system not possible with traditional spirometry. There are currently several instruments on the market using different perturbations. We have compared a new respiratory oscillometry instrument, the tremoflo, with Impulse Oscillometry (IOS). Patients with a physician's diagnosis of chronic obstructive lung disease (COPD) and healthy subjects were recruited. They underwent assessment of respiratory function with oscillometry using the IOS and tremoflo devices and the resulting impedance data from the two methods were compared. The two devices were also tested against a reference respiratory phantom with variable resistances. Whereas both devices detected impairments in the patients' lung function commensurate with small airways pathology, the tremoflo appeared to be more sensitive than the IOS. We found systematic differences between the two instruments especially for reactance measurements where the area over the reactance curve (AX) was significantly lower with the IOS compared with the tremoflo (p < 0.001). Moreover, the agreement between the two devices was reduced with increasing severity of the disease as determined with a Bland-Altman test. Testing both instruments against a respiratory phantom unit confirmed that the resistance measured by the tremoflo compares closely with the known resistance of test loads, whereas the IOS'resistance correlated with a test load of 0.19, kPa.s.L-1 at higher loads it deviated significantly from the known resistance (p < 0.0028). We conclude that the absolute values measured with the two devices may not be directly comparable and suggest that differences in the calibration procedures might account for the differences. en_US
dc.language.iso eng en_US
dc.publisher Nature en_US
dc.subject Multidisciplinary Sciences en_US
dc.subject.classification Sciences en_US
dc.title Oscillometry in Chronic Obstructive Lung Disease : In vitro and in vivo evaluation of the impulse oscillometry and tremoflo devices en_US
dc.type Article, peer reviewed scientific en_US
dc.contributor.department Malmö University. Faculty of Health and Society
dc.contributor.department Malmö University. Biomedical Sciences (BMV)
dc.identifier.doi 10.1038/s41598-019-48039-x en_US
dc.subject.srsc Research Subject Categories::NATURAL SCIENCES en_US
dc.relation.ispartofpublication Scientific Reports;1
dc.relation.ispartofpublicationvolume 9 en_US
dc.description.authorversion No en_US
dc.identifier.isiid 000480385200011
dc.identifier.pmid 31406190
dcterms.identifier.OAurl https://www.nature.com/articles/s41598-019-48039-x en_US
dc.format.artNo 11618 en_US
dc.format.sPage 11618 en_US
 Find Full text Files for download
Icon

This item appears in the following Collection(s)

Overview

Search


Browse

My Account

Statistics