Improvement of hand sensibility resulting from application of anaesthetic cream on the forearm : importance of dose and time

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Improvement of hand sensibility resulting from application of anaesthetic cream on the forearm : importance of dose and time

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Publication Article, peer reviewed scientific
Title Improvement of hand sensibility resulting from application of anaesthetic cream on the forearm : importance of dose and time
Author Saleem, Shifa ; Rosén, Birgitta ; Engblom, Johan ; Björkman, Anders
Research Centre Biofilms - Research Center for Biointerfaces
Date 2015
English abstract
Introduction: A local anaesthetic cream, EMLA (R), applied temporarily to the forearm can improve sensory functions in the hands, both in healthy individuals and in patients with nerve injury. The treatment concept is an example of guided plasticity where the dynamic capacity of the central nervous system is used for therapeutic purposes. However, the optimal dose and duration of the anaesthetic cream is not known and this is addressed here. Methods: Sixty healthy volunteers participated in this experimental study. They were randomised to one of six groups of 10 and received either 10 g or 20 g of EMLA (R) on the volar part of the forearm for either 60, 90 or 120 min, respectively. Outcome measures were touch thresholds and discriminative touch in digits II and V. Results: There was a statistically significant improvement in touch threshold as well as discriminative touch in all six groups. However, there were no statistically significant differences between the six different dose and duration combinations. Conclusions: It is concluded that 10 g of EMLA (R) applied to the volar part of the forearm for 60 min may be adequate to induce improved hand sensibility.
DOI https://doi.org/10.1177/1758998315595824 (link to publisher's fulltext.)
Publisher Sage
Host/Issue Hand therapy;4
Volume 20
ISSN 1758-9983
Language eng (iso)
Subject Local anaesthesia
neuronal plasticity
guided plasticity
touch perception
discriminative touch
Medicine
Research Subject Categories::MEDICINE
Handle http://hdl.handle.net/2043/30256 Permalink to this page
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