Improvement of hand sensibility resulting from application of anaesthetic cream on the forearm : importance of dose and time

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Improvement of hand sensibility resulting from application of anaesthetic cream on the forearm : importance of dose and time

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dc.contributor.author Saleem, Shifa
dc.contributor.author Rosén, Birgitta
dc.contributor.author Engblom, Johan
dc.contributor.author Björkman, Anders
dc.date.accessioned 2019-10-21T10:53:42Z
dc.date.available 2019-10-21T10:53:42Z
dc.date.issued 2015 en_US
dc.identifier.issn 1758-9983 en_US
dc.identifier.uri http://hdl.handle.net/2043/30256
dc.description.abstract Introduction: A local anaesthetic cream, EMLA (R), applied temporarily to the forearm can improve sensory functions in the hands, both in healthy individuals and in patients with nerve injury. The treatment concept is an example of guided plasticity where the dynamic capacity of the central nervous system is used for therapeutic purposes. However, the optimal dose and duration of the anaesthetic cream is not known and this is addressed here. Methods: Sixty healthy volunteers participated in this experimental study. They were randomised to one of six groups of 10 and received either 10 g or 20 g of EMLA (R) on the volar part of the forearm for either 60, 90 or 120 min, respectively. Outcome measures were touch thresholds and discriminative touch in digits II and V. Results: There was a statistically significant improvement in touch threshold as well as discriminative touch in all six groups. However, there were no statistically significant differences between the six different dose and duration combinations. Conclusions: It is concluded that 10 g of EMLA (R) applied to the volar part of the forearm for 60 min may be adequate to induce improved hand sensibility. en_US
dc.format.extent 6 en_US
dc.language.iso eng en_US
dc.publisher Sage en_US
dc.subject Local anaesthesia en_US
dc.subject neuronal plasticity en_US
dc.subject guided plasticity en_US
dc.subject touch perception en_US
dc.subject discriminative touch en_US
dc.subject.classification Medicine en_US
dc.title Improvement of hand sensibility resulting from application of anaesthetic cream on the forearm : importance of dose and time en_US
dc.type Article, peer reviewed scientific en_US
dc.contributor.department Malmö University. Faculty of Health and Society
dc.contributor.department Malmö University. Biomedical Sciences (BMV)
dc.identifier.doi 10.1177/1758998315595824 en_US
dc.subject.srsc Research Subject Categories::MEDICINE en_US
dc.relation.ispartofpublication Hand therapy;4
dc.relation.ispartofpublicationvolume 20 en_US
dc.description.authorversion No en_US
dc.identifier.isiid 000212825500001
dc.contributor.centre Malmö University. Biofilms - Research Center for Biointerfaces en_US
dc.format.ePage 114 en_US
dc.format.sPage 109 en_US
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