Detecting reduced bone mineral density from dental radiographs using statistical shape models.

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Detecting reduced bone mineral density from dental radiographs using statistical shape models.

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dc.contributor.author Allen, P Danny
dc.contributor.author Graham, Jim
dc.contributor.author Farnell, Damian J
dc.contributor.author Harrison, Elizabeth J
dc.contributor.author Jacobs, Reinhilde
dc.contributor.author Nicopolou-Karayianni, Kety
dc.contributor.author Lindh, Christina
dc.contributor.author van der Stelt, Paul F
dc.contributor.author Horner, Keith
dc.contributor.author Devlin, Hugh
dc.date.accessioned 2008-01-21T15:30:24Z
dc.date.available 2008-01-21T15:30:24Z
dc.date.issued 2007
dc.identifier.citation 601-10 en
dc.identifier.uri http://hdl.handle.net/2043/5541
dc.description.abstract We describe a novel method of estimating reduced bone mineral density (BMD) from dental panoramic tomograms (DPTs), which show the entire mandible. Careful expert width measurement of the inferior mandibular cortex has been shown to be predictive of BMD in hip and spine osteopenia and osteoporosis. We have implemented a method of automatic measurement of the width by active shape model search, using as training data 132 DPTs of female subjects whose BMD has been established by dual-energy X-ray absorptiometry. We demonstrate that widths measured after fully automatic search are significantly correlated with BMD, and exhibit less variability than manual measurements made by different experts. The correlation is highest towards the lateral region of the mandible, in a position different from that previously employed for manual width measurement. An receiver-operator characterstic (ROC) analysis for identifying osteopenia (T < -1: BMD more than one standard deviation below that of young healthy females) gives an area under curve (AUC) value of 0.64. Using a minimal interaction to initiate active shape model (ASM) search, the measurement can be made at the optimum region of the mandible, resulting in an AUC value of 0.71. Using an independent test set, AUC for detection of osteoporosis (T < -2.5) is 0.81. en
dc.language.iso eng en
dc.subject.classification Medicine en
dc.title Detecting reduced bone mineral density from dental radiographs using statistical shape models. en
dc.type Article, peer reviewed scientific en
dc.contributor.department Malmö University. Faculty of Odontology en
dc.subject.srsc Research Subject Categories::ODONTOLOGY::Radiological research en
dc.relation.ispartofpublication IEEE transactions on information technology in biomedicine;6 en
dc.relation.ispartofpublicationvolume 11 en
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