Interactions between chitosan-modified particles and mucin-coated surfaces

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Interactions between chitosan-modified particles and mucin-coated surfaces

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dc.contributor.author Svensson, Olof
dc.contributor.author Thuresson, Krister
dc.contributor.author Arnebrant, Thomas
dc.date.accessioned 2008-08-19T14:23:42Z
dc.date.available 2008-08-19T14:23:42Z
dc.date.issued 2008
dc.identifier.issn 0021-9797 en_US
dc.identifier.uri http://hdl.handle.net/2043/6476
dc.description.abstract Lipid-based particles (Cubosome® particles) were surface-modified by chitosan and the ratio between particles and chitosan was optimized to minimize the free chitosan concentration in the dispersion. The modified particles were characterized by electrophoretic measurements and the pH dependence of the zeta potential could be directly related to the protonation of chitosan. Interaction between the modified particles and mucin-coated silica surfaces were subsequently investigated in situ by ellipsometry to assess the mucoadhesive properties at physiologically relevant conditions. The result showed that a substantial amount of modified particles was adsorbed to mucin-coated silica surfaces at both pH 4 and pH 6, probably due to electrostatic interactions between amino groups in chitosan and negatively charged groups in mucin. Furthermore, the amount of bound particles decreased by less than 15% upon rinsing indicating relatively strong interactions. This investigation demonstrates that ellipsometry is a useful tool to study mucoadhesive properties of particles in the submicrometer range. Moreover, the novel chitosan-modified particles may be of interest for mucosal drug delivery applications. en
dc.format.extent 5
dc.language.iso eng en
dc.publisher Elsevier Inc. en
dc.subject mucin en
dc.subject chitosan en
dc.subject mucoadhesion en
dc.subject drug delivery en
dc.subject particle en
dc.subject ellipsometry en
dc.subject.classification Sciences en
dc.title Interactions between chitosan-modified particles and mucin-coated surfaces en
dc.type Article, peer reviewed scientific en
dc.contributor.department Malmö University. Faculty of Health and Society en
dc.identifier.doi 10.1016/j.jcis.2008.06.013 en
dc.subject.srsc Research Subject Categories::NATURAL SCIENCES::Chemistry::Physical chemistry en
dc.subject.srsc Research Subject Categories::PHARMACY::Pharmaceutical chemistry en
dc.relation.ispartofpublication Journal of Colloid and Interface Science;325 en
dc.relation.ispartofpublicationvolume 2 en
dc.format.ePage 350
dc.format.sPage 346
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