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  • 1. Khan, Rehan
    et al.
    Witek, Lukasz
    Breit, Matthew
    Colon, Dinely
    Tovar, Nick
    Janal, Malvin N.
    Jimbo, Ryo
    Malmö högskola, Faculty of Odontology (OD).
    Coelho, Paulo G.
    Bone Regenerative Potential of Modified Biphasic Graft Materials2015In: Implant Dentistry, ISSN 1056-6163, E-ISSN 1538-2982, Vol. 24, no 2, p. 149-154Article in journal (Refereed)
    Abstract [en]

    Purpose: To investigate the bone regenerative effect of polymer and collagen incorporation to synthetic bone graft materials. Materials and Methods: The bone ingrowth of biphasic graft materials was tested in a rabbit calvaria defect model after chemical characterization: HA/TCP (25%/75%) with collagen, HA/TCP (25%/75%) without collagen, (HA/TCP)/PLGA (85%/15%) with collagen, (HA/TCP)/PLGA (65%/35%) with collagen and a commercially available (HA/TCP)/PLGA (50%/50%) (ReOss T, Intra-Lock International, Boca Raton, FL) was used as control. After 4 and 8 weeks, the retrieved samples were subjected to histomorphometrical analysis. Results: Histomorphometry presented no significant differences concerning the bone formation between the different groups at both 4 and 8 weeks. Evidently, the (HA/TCP)/PLGA (65%/35%) with collagen presented the least amount of soft tissue incorporation within the defect. The same group possessed higher amounts of bone graft material within the defect throughout the 8-week observation period, whereas the other groups seemed to decrease in volume from 4 to 8 weeks. Conclusion: Changing the PLGA percentage to 35% within the biphasic graft material seemed to maintain its volume and prevented soft tissue migration, which could be clinically beneficial.

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