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  • 1.
    Chrcanovic, Bruno
    et al.
    Malmö högskola, Faculty of Odontology (OD). Malmö högskola, Biofilms Research Center for Biointerfaces.
    Kisch, Jenö
    Albrektsson, Tomas
    Malmö högskola, Faculty of Odontology (OD). Malmö högskola, Biofilms Research Center for Biointerfaces.
    Wennerberg, Ann
    Malmö högskola, Faculty of Odontology (OD). Malmö högskola, Biofilms Research Center for Biointerfaces.
    Is the intake of selective serotonin reuptake inhibitors associated with an increased risk of dental implant failure?2017In: International Journal of Oral and Maxillofacial Surgery, ISSN 0901-5027, E-ISSN 1399-0020, Vol. 46, no 6, p. 782-788Article in journal (Refereed)
    Abstract [en]

    The aim of this retrospective study was to investigate the association between the intake of selective serotonin reuptake inhibitors (SSRIs) and the risk of dental implant failure. Patients were included if they were taking SSRIs only and no other medication, did not present any other systemic condition or compromising habits (bruxism, smoking, snuff), and complied with the use of prophylactic antibiotics for implant surgery. The multivariate generalized estimating equation (GEE) method and multilevel mixed-effects parametric survival analysis were used to test the association between SSRI exposure (predictor variable) and the risk of implant failure (outcome variable), adjusting for several potential confounders (other variables). The total number of implants with information available and meeting the necessary eligibility criteria was 931 (35 failures). These were placed in 300 patients. The implant failure rate was 12.5% for SSRI users and 3.3% for non-users (P = 0.007). Kaplan–Meier analysis showed a statistically significant difference in the cumulative survival rate (P < 0.001). The multivariate GEE model did not show a statistically significant association between SSRI intake and implant failure (P = 0.530), nor did the multilevel model (P = 0.125). It is suggested that the intake of SSRIs may not be associated with an increased risk of dental implant failure.

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