Is the intake of selective serotonin reuptake inhibitors associated with an increased risk of dental implant failure?

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Is the intake of selective serotonin reuptake inhibitors associated with an increased risk of dental implant failure?

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Publication Article, peer reviewed scientific
Title Is the intake of selective serotonin reuptake inhibitors associated with an increased risk of dental implant failure?
Author Chrcanovic, Bruno ; Kisch, Jenö ; Albrektsson, Tomas ; Wennerberg, Ann
Research Centre Biofilms - Research Center for Biointerfaces
Date 2017
English abstract
The aim of this retrospective study was to investigate the association between the intake of selective serotonin reuptake inhibitors (SSRIs) and the risk of dental implant failure. Patients were included if they were taking SSRIs only and no other medication, did not present any other systemic condition or compromising habits (bruxism, smoking, snuff), and complied with the use of prophylactic antibiotics for implant surgery. The multivariate generalized estimating equation (GEE) method and multilevel mixed-effects parametric survival analysis were used to test the association between SSRI exposure (predictor variable) and the risk of implant failure (outcome variable), adjusting for several potential confounders (other variables). The total number of implants with information available and meeting the necessary eligibility criteria was 931 (35 failures). These were placed in 300 patients. The implant failure rate was 12.5% for SSRI users and 3.3% for non-users (P = 0.007). Kaplan–Meier analysis showed a statistically significant difference in the cumulative survival rate (P < 0.001). The multivariate GEE model did not show a statistically significant association between SSRI intake and implant failure (P = 0.530), nor did the multilevel model (P = 0.125). It is suggested that the intake of SSRIs may not be associated with an increased risk of dental implant failure.
DOI https://doi.org/10.1016/j.ijom.2017.01.016 (link to publisher's fulltext.)
Link http://www.ijoms.com/article/S0901-5027(17)30036-X... (external link to publication)
Publisher Elsevier
Host/Issue International Journal of Oral and Maxillofacial Surgery;6
Volume 46
ISSN 0901-5027
Pages 782-788
Language eng (iso)
Subject Dental implant
Implant failure
Selective serotonin reuptake inhibitors
Multivariate generalized estimating equation analysis
Multilevel mixed-effects parametric survival analysis
Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/22409 Permalink to this page
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